Geyza Nogueira de Almeida Armiliato, Mateus Jorge Nardelli, Sílvia Marinho Ferolla, Érika Cristina Lima, Quelson Coelho Lisboa, Paula Vieira Teixeira Vidigal, Teresa Cristina de Abreu Ferrari, Claudia Alves Couto
Introduction: Non-alcoholic fatty liver disease (NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH) and liver fibrosis. Recently, consumption of high fruc-tose corn syrup (HFCS) has been associated with NAFLD de-velopment. Objective: The aim of this study was to investigate the re-lationship between consumption of HFCS and NAFLD associ-ated metabolic factors and disease progression. Methods: This cross-sectional study included 51 patientswith biopsy-proven NAFLD who underwent biochemical tests,anthropometrical assessment and full-day dietary evaluationincluding industrialized beverages quantification. Results: Individuals were 80% female, with 54 ± 12 yearsold, 96% with central obesity, 75% with insulin resistance ordiabetes mellitus and were separated according to industrial-ized beverage intake: < 7 and ≥ 7 coups/week (i.e., daily).Daily consumption of HFCS was associated with obesity (P =0.04), hypertriglyceridemia (P = 0.05), higher serum triglyc-erides (P = 0.03) and VLDL (P = 0.01). There was a signifi-cant correlation (R = 0.29; P = 0.04) between consumptionof industrialized beverages and increased serum triglycerides.We found no association between daily HFCS intake andNASH diagnosis or presence of fibrosis.
Conclusion: Excessive consumption of HFCS in industrializedbeverages was associated with obesity, hypertriglyceridemiaand high levels of blood triglycerides in patients with NAFLD.