Consumption of Fructose Rich Industrialized Beverages in Patients with Biopsy-Proven Non-alcoholic Fatty Liver Disease: a Cross-Sectional Study

• Armiliato, Geyza Nogueira de Almeida ^[1] ; Nardelli, Mateus Jorge ^[1] ; Ferolla, Sílvia Marinho ^[1] ; Lima, Érika Cristina ^[1] ; Lisboa, Quelson Coelho ^[1] ; Vidigal, Paula Vieira Teixeira ^[1] ; Ferrari, Teresa Cristina de Abreu ^[1] ; Alves Couto, Claudia ^[1]
  1. [1] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
• Localización: Nutrición clínica y dietética hospitalaria, ISSN 0211-6057, Vol. 40, Nº. 2, 2020, págs. 17-24
• Idioma: inglés
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• Resumen

  • Introduction: Non-alcoholic fatty liver disease (NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH) and liver fibrosis. Recently, consumption of high fruc-tose corn syrup (HFCS) has been associated with NAFLD de-velopment. Objective: The aim of this study was to investigate the re-lationship between consumption of HFCS and NAFLD associ-ated metabolic factors and disease progression. Methods: This cross-sectional study included 51 patientswith biopsy-proven NAFLD who underwent biochemical tests,anthropometrical assessment and full-day dietary evaluationincluding industrialized beverages quantification. Results: Individuals were 80% female, with 54 ± 12 yearsold, 96% with central obesity, 75% with insulin resistance ordiabetes mellitus and were separated according to industrial-ized beverage intake: < 7 and ≥ 7 coups/week (i.e., daily).Daily consumption of HFCS was associated with obesity (P =0.04), hypertriglyceridemia (P = 0.05), higher serum triglyc-erides (P = 0.03) and VLDL (P = 0.01). There was a signifi-cant correlation (R = 0.29; P = 0.04) between consumptionof industrialized beverages and increased serum triglycerides.We found no association between daily HFCS intake andNASH diagnosis or presence of fibrosis.

    Conclusion: Excessive consumption of HFCS in industrializedbeverages was associated with obesity, hypertriglyceridemiaand high levels of blood triglycerides in patients with NAFLD.