Resumen de Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene

V. Chaia, Sofía Kimi Uehara, Carla Lima D'Andrea, Juliana Nogueira, Marcia Fófano do Lago, Marcelly Cunha Oliveira Dos Santos Lopes, Edna Maria Morais Oliveira, Eliane Lopes Rosado

• Introduction:

  Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable.

  Objective:

  To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype.

  Methods:

  Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m2 (n = 17); G2: > 45 kg/m2 (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively.

  Results:

  G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2.

  Conclusion:

  Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.