Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene

• Autores: V. Chaia, Sofía Kimi Uehara, Carla Lima D'Andrea, Juliana Nogueira, Marcia Fófano do Lago, Marcelly Cunha Oliveira Dos Santos Lopes, Edna Maria Morais Oliveira, Eliane Lopes Rosado
• Localización: Nutrición hospitalaria: Órgano oficial de la Sociedad Española de Nutrición Clínica y Metabolismo (SENPE), ISSN-e 1699-5198, ISSN 0212-1611, Vol. 28, Nº. 3, 2013, págs. 694-700
• Idioma: inglés
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• Resumen

  • Introduction:

    Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable.

    Objective:

    To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro genotype.

    Methods:

    Were selected 25 morbidly obese women. Groups were formed according to body mass index (BMI) [G1: 40-45 kg/m2 (n = 17); G2: > 45 kg/m2 (n = 8)]. Anthropometric, glycemia and insulinemia assessments (fasting, 60 and 120 minutes after high polyunsaturated fatty acids meal) were carried out. The insulin resistance (IR) and insulin sensitivity (IS) were assessed by HOMA-IR and QUICKI respectively.

    Results:

    G2 had higher BMI and waist circumference, compared to G1, impaired fasting glucose, low IS and higher IR. The postprandial glucose was normal, but there was a higher insulin peak one hour after the meal in G2.

    Conclusion:

    Increased BM and VA were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype.