Acceso usuarios
Daniel Antonio de Luis Román, Rocío Aller de la Fuente, Olatz Izaola Jáuregui, Manuel González Sagrado, Rosa Conde Vicente
Background and objective The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects.
Patients and method A sample of 261 obese subjects were enrolled in a consecutive prospective way, from May 2011 to July 2012 in a tertiary hospital. In the basal visit, patients were randomly allocated during 3 months to Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet).
Results One hundred and ninety seven patients (73.2%) had the genotype G-308G and 64 (26.8%) patients had the genotype G-308A. There were no significant differences between the effects (on weight, body mass index (BMI), waist circumference, fat mass) in either genotype group with both diets. With the diet type P and in genotype G-308G, glucose levels (-6.7(22.1) mg/dl vs -3.7(2.2) mg/dl: p = 0.02), HOMA-R (-0.6(2.1) units vs -0.26(3.1) units: p = 0.01), insulin levels (-1.7(6.6) UI/L vs -0.6(7.1) UI/L: p = 0.009), total cholesterol levels (-15.3(31.1) mg/dl vs -8.4(22.1) mg/dl: p = 0.01), LDL cholesterol levels (-10.7(28.1) mg/dl vs -3.8(21.1) mg/dl: p = 0.008) and triglycerides (-12.1(52.1) mg/dl vs -6.6(43.1) mg/dl: p = 0.02) decreased.
Conclusion Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet.
