Acceso usuarios
Background and objective The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects.
Patients and method A sample of 261 obese subjects were enrolled in a consecutive prospective way, from May 2011 to July 2012 in a tertiary hospital. In the basal visit, patients were randomly allocated during 3 months to Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet).
Results One hundred and ninety seven patients (73.2%) had the genotype G-308G and 64 (26.8%) patients had the genotype G-308A. There were no significant differences between the effects (on weight, body mass index (BMI), waist circumference, fat mass) in either genotype group with both diets. With the diet type P and in genotype G-308G, glucose levels (-6.7(22.1) mg/dl vs -3.7(2.2) mg/dl: p = 0.02), HOMA-R (-0.6(2.1) units vs -0.26(3.1) units: p = 0.01), insulin levels (-1.7(6.6) UI/L vs -0.6(7.1) UI/L: p = 0.009), total cholesterol levels (-15.3(31.1) mg/dl vs -8.4(22.1) mg/dl: p = 0.01), LDL cholesterol levels (-10.7(28.1) mg/dl vs -3.8(21.1) mg/dl: p = 0.008) and triglycerides (-12.1(52.1) mg/dl vs -6.6(43.1) mg/dl: p = 0.02) decreased.
Conclusion Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet.
