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Introducción: El uso de productos naturales como coadyuvantes en el manejo de la hipertensión arterial ha despertado creciente interés. Petroselinum sativum (perejil) posee propiedades vasorrelajantes, diuréticas y antioxidantes descritos en estudios experimentales; sin embargo, la evidencia clínica en humanos es limitada, particularmente en relación con su efecto dosis–respuesta y su impacto sobre marcadores renales tempranos.
Objetivo: Evaluar el efecto de diferentes dosis de extracto liofilizado de Petroselinum sativum sobre la microalbuminuria en pacientes hipertensos.
Métodos: Ensayo clínico realizado en un hospital en Lima con un total de 84 participantes entre los meses de septiembre y octubre del 2025, el presente estudio tuvo una duración de cuatro semanas de tratamiento con cuatro grupos paralelos: control, dosis 0,5 g, 1 g y 2 g de extracto liofilizado de Petroselinum sativum (n = 21 por grupo). Se evaluaron presión arterial sistólica (PAS) y diastólica (PAD), volumen de orina de 24 horas, albúmina urinaria, creatinina urinaria y cociente albúmina/creatinina (ACR) al inicio y al final del seguimiento. Se utilizaron ANOVA o Kruskal–Wallis según distribución, con pruebas post-hoc ajustadas por el método de Holm. Adicionalmente, se realizó análisis de covarianza (ANCOVA) ajustando los valores finales de presión arterial por los valores basales.
Resultados: No se observaron diferencias significativas entre grupos en albúmina urinaria, creatinina urinaria ni ACR en las comparaciones basal, final o del cambio (p > 0,05).
Conclusiones: No se evidenció un efecto diferencial sobre la microalbuminuria ni otros marcadores urinarios en el corto plazo. Estos hallazgos respaldan un potencial rol del extracto como estrategia complementaria para el control de la presión arterial, aunque se requieren estudios con mayor seguimiento para evaluar efectos renales sostenidos y seguridad a largo plazo.
Introduction: The use of natural products as adjuvants in the management of arterial hypertension has attracted increasing interest. Petroselinum sativum (parsley) has been shown to possess vasorelaxant, diuretic, and antioxidant properties in experimental studies; however, clinical evidence in humans remains limited, particularly regarding its dose–response effect and its impact on early renal markers.
Objective: To evaluate the effect of different doses of lyophilized Petroselinum sativum extract on microalbuminuria in adults after four weeks of intervention.Methods: A four-week clinical trial was conducted with four parallel groups: control, 0.5 g, 1 g, and 2 g doses of lyophilized Petroselinum sativum extract (n = 21 per group). Systolic (SBP) and diastolic blood pressure (DBP), 24-hour urine volume, urinary albumin, urinary creatinine, and the albumin-to-creatinine ratio (ACR) were assessed at baseline and at the end of follow-up. ANOVA or Kruskal–Wallis tests were applied according to data distribution, with post-hoc comparisons adjusted using the Holm method. Additionally, analysis of covariance (ANCOVA) was performed to adjust final blood pressure values for baseline measurements.
Results: At baseline, significant differences between groups were observed for SBP (p = 0.0465), with a more pronounced imbalance for DBP (p < 0.0001). At the end of the intervention, SBP differed significantly among groups (p < 0.0001), with lower values in the 2 g group (133.33 ± 5.29 mmHg) compared with the control group (146.67 ± 4.59 mmHg). Final DBP also showed significant differences between groups (p < 0.0001). Change analysis (Δ final–baseline) demonstrated a greater reduction in SBP in the 2 g group (−11.76 ± 4.43 mmHg) com pared with the control group (−1.00 [−2.00; −1.00] mmHg; p < 0.0001), as well as a greater decrease in DBP (p = 0.0005). ANCOVA confirmed that the effect of treatment group on final SBP and DBP was independent of baseline values (p < 0.0001). No significant differences between groups were observed in urinary albumin, urinary creatinine, or ACR at baseline, at the end of follow-up, or in change analyses (p > 0.05).
Conclusions: Lyophilized Petroselinum sativum extract demonstrated a significant, dose-dependent antihypertensive effect, particularly at a dose of 2 g/day, after four weeks of intervention. No differential effect on microalbuminuria or other urinary markers was observed in the short term. These findings support a potential role for the extract as a complementary strategy for blood pressure control; however, studies with longer follow-up are required to assess sustained renal effects and long-term safety.
