Acceso usuarios
Indonesia
Background: Obesity is a risk factor associated with car-diovascular disease. Apolipoprotein B (ApoB) is the main pro-tein in atherogenic lipoproteins and a strong predictor of car-diovascular risk. Omega-3 fatty acids have been shown toreduce plasma triglycerides and total ApoB levels in individu-als with metabolic syndrome. This study aims to analyze theeffect of omega-3 administration on ApoB-100 levels in ado-lescents with obesity.
Methods: This study was an experimental study with a pre-and post-test design, conducted by health students fromFebruary to April 2025 in Makassar. A total of 90 individuals metthe inclusion criterion of a body mass index (BMI) ≥ 25 kg/m².ApoB-100 levels were measured using the Human Apoli -poprotein B1 ELISA Kit, and lipid profiles were assessed usingan automated clinical chemistry analyzer with enzymatic colori-metric methods. 37 participants completed all procedures, di-vided into two groups: the control group (n=20), which re-ceived nutritional counseling, and the intervention group(n=17), which received 1200 mg omega-3 supplements dailyfor four weeks.
Results: The average age was 18.59 ± 0.62 years in theintervention group and 18.30 ± 0.57 years in the controlgroup. In the intervention group, ApoB-100 levels significantlydecreased from 1768.23 ± 335.18 to 1410.20 ± 191.03 ug/ml(p < 0.001). The control group showed an increase from1582.29 ± 426.95 to 1760.29 ± 507.65 ug/ml (p = 0.156).
Conclusion: This study showed Omega-3 supplementationsignificantly reduced ApoB-100 levels in obese adolescents,suggesting its potential role in reducing cardiovascular risk.
