Blood glucose homeostasis, birth weight, and pancreas of rat pups during pregnancy the mother is intervened with foodsubstitution beef bone marrow

• Made TANGKAS ^[1] ; Linda Ayu Rizka PUTRI ^[1] ; Hasanah HASANAH ^[1]
  1. [1] Tadulako University

     Tadulako University

     Indonesia

     
• Localización: Nutrición clínica y dietética hospitalaria, ISSN 0211-6057, Vol. 45, Nº. 1, 2025, págs. 269-273
• Idioma: inglés
• DOI: 10.12873/451tangkas
• Enlaces
  • Texto completo
• Resumen

  • Background: The growth of the intrauterine pancreas in the fetus is very dependent on the mother's nutritional intake during pregnancy. Previous research on animal models found that mother rats during pregnancy who were given low-protein feed gave birth to offspring with lower pancreatic weight compared to rat offspring given normal diet. This study aims to evaluate the potential of feed nutrients substituted for bovine bone marrow in increasing intrauterine pancreatic growth with biomarkers of glucose homeostasis, birth weight and pancreatic weight in rat offspring.

    Methods: This study employs an experimental study with in vivo design. During pregnancy, the Sprague Dawley rat animal model used in this study was intervened with Low Protein Feed (LPF), Normal Feed (NF) and Bovine Bone Marrow Substitution Feed (BBMSF). All formulated feeds are made isocaloric.

    Results: there was a significant difference (α <0.05) in the blood glucose of rat offspring from mothers who were intervened with LPF, NF and BBMSF at the age of 60 days. Rat pups whose mothers were intervened with LPF, NF, and BBMSF during pregnancy had significant differences in body weight (α<0.05). There was no significant difference (α > 0.05) in the weight of the pancreas of rat offspring from mothers who were intervened with LPF, NF and BBMSF at the ages of 30 and 60 days.

    Conclusion: Rat pups from mothers who were intervened during pregnancy with bovine bone marrow substitute feed had a better ability to maintain blood glucose homeostasis, had a higher average birth weight and pancreatic weight compared to rat pups from NF and LPF mothers.

• Referencias bibliográficas
  • Sayem A, Arya A, Karimian H, Krishnasamy N, Ashok Hasamnis A, Hossain C. Action of Phytochemicals on Insulin Signaling Pathways Accelerating...
  • Xiong Y, Lei QY, Zhao S, Guan KL. Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK. Cold Spring Harb Symp Quant...
  • Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human β-Cell Proliferation and Intracellular Signaling. Diabetes. 2012 Sep 1;61(9):2205–13.
  • Dilworth L, Facey A, Omoruyi F. Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues. Int J Mol Sci. 2021 Jan;22(14):7644.
  • Belkacemi L, Nelson DM, Desai M, Ross MG. Maternal Undernutrition Influences Placental-Fetal Development1. Biol Reprod. 2010 Sep 1;83(3):325–31.
  • Ueno S, Aung MN, Yuasa M, Ishtiaq A, Khin ET, Latt TS, et al. Association between Dietary Habits and Type 2 Diabetes Mellitus in Yangon, Myanmar:...
  • Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes...
  • Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R, et al. Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments....
  • Su Y, Jiang X, Li Y, Li F, Cheng Y, Peng Y, et al. Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse...
  • Jamshed S, Khan F, Begum A, Barkat Ali B, Akram Z, Ariff M. Frequency of Low Birth Weight and its Relationship With Maternal Nutritional and...
  • Devaguru A, Gada S, Potpalle D, Dinesh Eshwar M, Purwar D. The Prevalence of Low Birth Weight Among Newborn Babies and Its Associated Maternal...
  • Blasetti A, Quarta A, Guarino M, Cicolini I, Iannucci D, Giannini C, et al. Role of Prenatal Nutrition in the Development of Insulin Resistance...
  • Blasetti A, Quarta A, Guarino M, Cicolini I, Iannucci D, Giannini C, et al. Role of Prenatal Nutrition in the Development of Insulin Resistance...
  • Tangkas IM, Sulaeman A, Anwar F, Suprayogi A, Estuningsih S, Rokhmah UF. Multinutrients from Local Cattle Bone Marrow in Central Sulawesi...
  • Tangkas IM, Sulaeman A, Anwar F, Suprayogi A, Estuningsih S. The Feed of Local Beef Bone Marrow Substitution during Pregnancy affects the...
  • Jensen T, Kiersgaard M, Sørensen D, Mikkelsen L. Fasting of mice: a review. Lab Anim. 2013 Oct;47(4):225–40.
  • Chen M, Bergman R, Pacini G, Porte Jr D. Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased β-cell function....
  • Zhou D, Li XH, Lee SH, Heo G, Cui XS. Effects of alpha-linolenic acid and essential amino acids on the proliferation and differentiation of...
  • Burdge GC, Wootton SA. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J...
  • Yang J, Chang Q, Tian X, Zhang B, Zeng L, Yan H, et al. Dietary protein intake during pregnancy and birth weight among Chinese pregnant women...
  • Cox AR, Gottheil SK, Arany EJ, Hill DJ. The Effects of Low Protein During Gestation on Mouse Pancreatic Development and Beta Cell Regeneration....