Association between fibroblast growth factor-23 and vascular calcification in athletic patients: A meta-analysis

• Yan-Kun Luo ^[2] ; Huan Liu ^[1] ; Ye Chen ^[1] ; Rong-Shan Li ^[2] ; Yun Zhou ^[2]
  1. [1] Shanxi Medical University

     Shanxi Medical University

     China

     
  2. [2] Shanxi Provincial People’s Hospital
• Localización: Revista Internacional de Medicina y Ciencias de la Actividad Física y del Deporte, ISSN-e 1577-0354, Vol. 24, Nº. 95, 2024, págs. 524-537
• Idioma: inglés
• Títulos paralelos:
  • Asociación entre el factor de crecimiento de fibroblastos-23 y la calcificación vascular en pacientes atleticos: Un metanálisis
• Enlaces
  • Texto completo
• Resumen
  • español

    Objetivo: En la clínica, los pacientes atletas con enfermedad renal crónica a menudo se complican con calcificación vascular en el proceso de tratamiento de hemodiálisis de mantenimiento (MHD), y luego evolucionan a eventos cardiovasculares. El aumento de FGF-23 se asocia con aterosclerosis y función vascular anormal. Realizamos un metanálisis para examinar la asociación entre FGF-23 y calcificación vascular en pacientes atletas. Métodos: Se realizó una búsqueda bibliográfica sistemática en PubMed, EmBae y la biblioteca Cochrane para investigar la relación de FGF-23 y calcificación vascular en pacientes de hemodiálisis. La heterogeneidad se evaluó utilizando estadísticas I-cuadrado y Q. La diferencia de medias ponderada (DMP) o odds ratio (OR) y el intervalo de confianza del 95% (IC) en el grupo de hemodiálisis y el grupo sin hemodiálisis se agruparon adecuadamente. Resultados: Se incluyeron once estudios (1144 pacientes atletas). No hubo diferencia significativa en FGF-23 entre calcificación vascular y calcificación no vascular en pacientes atletas. No se encontró evidencia de heterogeneidad entre los estudios incluidos. Conclusión: El FGF-23 no mostró efecto sobre la progresión de la calcificación vascular en hemodiálisis de mantenimiento.

  • English

    Objective:In the clinic, athletic patients with chronic kidney disease are often complicated with vascular calcification in the process of maintenance hemodialysis (MHD) treatment, and then evolve into cardiovascular events. The increase of FGF-23 is associated with atherosclerosis and abnormal vascular function.We conducted a meta-analysis to examine the association between FGF-23 and vascular calcification in athletic patients.Methods:A systematic literature search was conducted in PubMed, EmBae, and the Cochrane library to investigate the relation of FGF-23 and vascular calcification in hemodialysis patients. The heterogeneity was assessed using I-square and Q statistics. Weighted mean difference (WMD) or odds ratio (OR) and 95% confidence interval (CI) in the hemodialysis group and non-hemodialysis group were appropriately pooled.Results:Eleven studies (1144 athletic patients) were included. There was no significant difference in FGF-23 between vascular calcification and non-vascular calcification in athletic patients. No evidence of heterogeneity was existent among the included studies.Conclusion:FGF-23 showed no effect on the progression of vascular calcification in maintenancehemodialysis.KEYWORDS:FGF-23; maintenance hemodialysis; Vascular calcification; Meta-analysis

• Referencias bibliográficas
  • Ades, A., Lu, G., & Higgins, J. (2005). The interpretation of random-effects meta-analysis in decision models. Medical Decision Making,...
  • Altman, D. G., & Bland, J. M. (2003). Interaction revisited: the difference between two estimates. bmj,326(7382), 219.
  • Cannata-Andía, J. B., Rodríguez-García, M., Carrillo-López, N., Naves-Díaz, M., & Díaz-López, B. (2006). Vascular calcifications:...
  • Chirakarnjanakorn, S., Navaneethan, S. D., Francis, G. S., & Tang, W. W. (2017). Cardiovascular impact in patients undergoing...
  • Davies, M. R., & Hruska, K. A. (2001). Pathophysiological mechanisms of vascular calcification in end-stage renal disease. Kidney...
  • Deeks, J. (2008). Analyzing data and undertaking meta-analyses In: Higgins J, Green S,eds. Cochrane Handbook for Systematic Reviews...
  • DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled clinical trials, 7(3), 177-188.
  • Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. Bmj, 315(7109),...
  • El Baz, T. Z., Khamis, O. A., Ahmed Gheith, O. A., Abd Ellateif, S. S., Abdallah, A. M., & Abd El Aal, H. C. (2017). Relation of fibroblast...
  • El Baz, T. Z., Khamis, O. A., Gheith, O. A. A., Abd Ellateif, S. S., Abdallah, A. M., & Abd El Aal, H. C. (2017). Relation of fibroblast...
  • Ganidagli, B., Nacar, H., Yildiz, Y. S., Dagli, H., Erken, E., Altunoren, O., & Gungor, O. (2019). The relationship between serum osteopontin...
  • Ganidagli, B., Nacar, H., Yildiz, Y. S., Dagli, H., Erken, E., Altunoren, O., & Gungor, O. (2019). The relationship between serum osteopontin...
  • Guérin, A. P., London, G. M., Marchais, S. J., & Metivier, F. (2000). Arterial stiffening and vascular calcifications in end‐stage...
  • Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh-Hain, J. A.,Tamez, H., Shah, A., . . . Jüppner, H. (2008). Fibroblast growth factor 23...
  • Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. Bmj, 327(7414), 557-560....
  • Inaba, M., Okuno, S., Imanishi, Y., Yamada, S., Shioi, A., Yamakawa, T., . . . Nishizawa, Y. (2006). Role of fibroblast growth factor-23 in...
  • Jasani, R., Hase, N., Kumar, R., Dedhia, P., Jamale, T., & Bajpai, D. (2018). Predictors of coronary calcification in Indian hemodialysis...
  • Jasani, R., Hase, N., Kumar, R., Dedhia, P., Jamale, T., & Bajpai, D. (2018). Predictors of coronary calcification in Indian hemodialysis...
  • Jean, G., Bresson, E., Lorriaux, C., Mayor, B., Hurot, J.-M., Deleaval, P., & Chazot, C. (2012). Increased levels of serum parathyroid...
  • Jean, G., Bresson, E., Terrat, J.-C., Vanel, T., Hurot, J.-M., Lorriaux, C., . . . Chazot, C. (2008). Peripheral vascular calcification...
  • Kurnatowska, I., Grzelak, P., Kaczmarska, M., Stefanczyk, L., & Nowicki, M. (2011). Serum osteoprotegerin is a predictor of progression...
  • Kurnatowska, I., Grzelak, P., Kaczmarska, M., Stefańczyk, L., & Nowicki, M. (2011). Serum osteoprotegerin is a predictor of progression...
  • Kuro-o, M. (2010). Overview of the FGF23-Klotho axis. Pediatric Nephrology, 25(4), 583-590.
  • Massy, Z., Mentaverri, R., Mozar, A., Brazier, M., & Kamel, S. (2008). The pathophysiology of vascular calcification: are...
  • McCullough, P. A., Sandberg, K. R., Dumler, F., & Yanez, J. E. (2004). Determinants of coronary vascular calcification in...
  • Mirams, M., Robinson, B. G., Mason, R. S., & Nelson, A. E. (2004). Bone as a source of FGF23: regulation by phosphate? Bone, 35(5), 1192-1199....
  • Moe, S. M., & Chen, N. X. (2008). Mechanisms of vascular calcification in chronic kidney disease. Journal of the American...
  • Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & PRISMA Group*, t. (2009). Preferred reporting items for systematic reviews and...
  • Moldovan, D., Moldovan, I., Rusu, C., Kacso, I., Patiu, I. M., & Gherman-Caprioara, M. (2014). FGF-23, vascular calcification,...
  • Nishizawa, Y., Jono, S., Ishimura, E., & Shioi, A. (2005). Hyperphosphatemia and vascular calcification in end-stage renal disease. Journal...
  • Ozkok, A., Kekik, C., Karahan, G.E., Sakaci, T., Ozel, A., Unsal, A., & Yildiz, A. (2013). FGF-23 associated with the progression...
  • San Norberto, E. M., Revilla, Á., Fernandez-Urbon, A., Gomez-Giralda, B.,Taylor, J. H., & Vaquero, C. (2021). Vascular calcification...
  • Spasovski, G. B. (2007). Bone health and vascular calcification relationships in chronic kidney disease. International urology and nephrology,...
  • Tamei, N., Ogawa, T., Ishida, H., Ando, Y., & Nitta, K. (2011). Serum fibroblast growth factor-23 levels and progression of aortic arch...
  • Tamei, N., Ogawa, T., Ishida, H., Ando, Y., & Nitta, K. (2011). Serum fibroblast growth factor-23 levels and progression of aortic arch...
  • Tobias, A. (1999). Assessing the influence of a single study in the meta-analysis estimate. Stata Tech. Bull., 47, 15-17.
  • Turan, M. N., Kircelli, F., Yaprak, M., Sisman, A. R., Gungor, O., Bayraktaroglu, S., . . . Ok, E. (2016). FGF-23 levels are associated...
  • Wells, G. A., Shea, B., O’Connell, D., Peterson, J., Welch, V., Losos, M., & Tugwell, P. (2000). The Newcastle-Ottawa Scale (NOS) for...