Acceso usuarios
Indonesia
Introduction: The global prevalence of Chronic KidneyDisease (CKD) is 9.1%, with an increase of 29.3% from 1990to 2018. A healthy diet with Extra Virgin Olive Oil (EVOO) consumption play a role in reducing inflammation and modulating gut microbiota in CKD patients. This study aims to assessthe effect of extra virgin olive oil on immune system plateletto-lymphocyte ratio (PLR) and Short Chain Fatty Acids (SCFA)in patients with Chronic Kidney Disease (CKD).
Methods: Randomized clinical trial at Dr. WahidinSudirohusodo Hospital Makassar on December 2022. The to-tal sample was 30 and divided by two groups, each groupboth intervention with EVOO 40 ml / day and control groupwith normal diet (15 patients ). Data were collected throughq uestionnaires and direct measurements for anthropometric (Body weight and Body height). Energy intake with twentyfour hours recall. platelet-to-lymphocyte ratio (PLR) throughroutine blood test and Short chan fatty acids (SCFA) throughPro Healthy Gut tests. Data were analyzed using SPSS version26 with t-test analysis.
Results: EVOO administration had a significant result on inflammatory markers and gut microbiota. The intervention grouphad increased energy composition (1370.63±147.76 to1690.63±147.76; p=0.000) and fat (19.93±7.25 to 57.93±7.25;p=0.000), accompanied by a decrease in Platelet-Lymphocyte Ratio (PLR) (210.76±80.20 to 169.89±54.22; p=0.026) and anincrease in Short Chain Fatty Acids (SCFA) in feces (6.86±4.42 to 16.98±15.47; p=0.021) . While the control group showed no significant changes.
Conclusion: Extra virgin olive oil (EVOO) had no significant effect on the nutritional status of patients with Chronic KidneyDisease (CKD), but reduced inflammation (decreased PLR). In addition improved gut microbiota health (increased SCFA).
