Resumen de The relationship between water intake and progressivity Glomerular filtration rate of chronic kidney disease patients

Munaqisah Munaqisah, Haerani A. Rasyid, Suryani As'ad, Nurpudji Astuti Taslim, Nur Ashari

• Introduction and objectives: The increasing incidenceof chronic kidney disease in Indonesia and several previousstudies assessing the relationship of water intake by evaluat-ing all inputs including total daily water intake as well as out-put (urine volume) found that there is a role of fluid input onthe progressivity of CKD which shows that patients who drinktoo much or little water tend to progress the failure of kidneyfunction faster so we raised this study to determine and im-portant implications for education of CKD patients regarding water intake.

  Methods: This prospective observational study entailsthe enrollment of CKD stage 3a, 3b and 4 outpatients fromHypertension Kidney Poluclinic at Dr. Wahidin SudirohusodoHospital and Makassar Satellite Hospital, The search for re-search subjects from October to December 2023 (11 sub-jects), followed by observation and data collection lastedfor a duration of 3 months (10 subjects) and was analyzedfrom March to April 2024. The daily average water intakewas measured using a 2-liter tumbler and 24-hour urinevolume was measured using a chamber pot and the resultswere recorded in a food diary. Creatinine levels (LFG) werecollected from red blood cells and urine osmolarity from 24-hour urine.

  Results: The correlation between average daily water in-take and delta creatinine was r= 0.151 (p=0.677), averagedaily water intake and delta eLFG was r= -0.196 (p=0.588), average daily water intake and 24-hour total urine volumewas r=0.625 (p=0.053), average daily water intake and deltaurine osmolarity was r= 0.608 (p=0.062). A p-value exceed-ing 0.05 indicates an insignificant correlation.

  Conclusions: The physiological function of the kidneyscan still function properly as evidenced by the amount of wa-ter given where the more the amount of water drunk, themore the amount of urine and urine osmolarity decreases.This study has not been able to prove the research hypothesis sis with research limitations.