Physical activity is widely recognized as a powerful clinical tool, enhancing quality of life and reducing mortality, also contributing to the treatment and/or prevention of several chronic diseases. Seventy years ago, the classical article by Morris et al. showed a lower incidence of coronary heart disease in physically active workers, when compared with their inactive counterparts. In the following decades, epidemiological data from longitudinal prospective studies showed a significant reduction on general and cardiovascular mortality, associated with the weekly energy expenditure (volume of exercise), with exercise intensity providing additional benefit.