The aim of research is determining the role of physical activity related to the managing chronic diseases in south American elderly populations. This research covers the significance of physical exercise in controlling chronic diseases among senior people in South America. As the area grapples with demographic transitions and a rising aging population, knowing the significance of regular exercise becomes vital. Engaging in physical exercise is beneficial for managing a number of health issues, such as diabetes, mental health, musculoskeletal health, and cardiovascular health. For measuring the research used SPSS software and generate result included descriptive statistic, correlation coefficient, the model summary, also that explain the chi square analysis between them. The research study highlights the need for customized fitness regimens that include strength, flexibility, cardio, and balancing activities while considering specific medical issues. Public health campaigns and community-based activities are seen as essential elements in promoting an active ageing culture and improving the general wellbeing of senior citizens. South American cultures may actively contribute to disease prevention, disease management, and enhanced quality of life for their ageing populations by realising the many advantages of physical exercise. Overall result founded that direct also significant link of physical activity in managing chronic diseases in the south American. Building healthier and more resilient ageing communities in the area requires funding programmes that encourage and support seniors' active lifestyles.