Diagnostic and Prognostic Role of Delta Neutrophil Index (DNI), With Emphasis on Gastrointestinal Disorders

• Amin Daemi ^[1] ; Zafer Yönden ^[1] ; Yavar Yousefi ^[2] ; Seyyedeh Touran Hosseini ^[3] ; Yusuf Döğüş ^[1] ; Ümit Karaoğullarından ^[1]
  1. [1] Cukurova University

     Cukurova University

     Turquía

     
  2. [2] Granen Medical Center, Malmö, Sweden
  3. [3] Department of Biotechnology, Institute of Natural and Applied Sciences, Cukurova University, Adana, Turkey

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• Localización: Academic Journal of Health Sciences: Medicina Balear, ISSN-e 2255-0560, Vol. 38, Nº. 5, 2023, págs. 55-60
• Idioma: inglés
• DOI: 10.3306/AJHS.2023.38.05.55
• Títulos paralelos:
  • Función diagnóstica y pronóstica del índice de neutrófilos delta (DNI), con énfasis en los trastornos gastrointestinales
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• Resumen
  • español

    Antecedentes: El índice delta de neutrófilos (DNI) es un nuevo biomarcador para el diagnóstico y el pronóstico de diversas enfermedades inflamatorias o infecciosas. El DNI es un índice de laboratorio que se determina dividiendo el número total de neutrófilos de sangre periférica por el número de granulocitos inmaduros. Sin embargo, hay pocos estudios que hayan examinado el uso potencial del DNI como biomarcador pronóstico en los trastornos gastrointestinales y sus infecciones asociadas. El propósito de este estudio fue explorar el papel del índice delta de neutrófilos (DNI) como biomarcador para determinar el pronóstico de afecciones infecciosas, especialmente en enfermedades gastrointestinales.

    Métodos: La investigación es una revisión bibliográfica. Para la revisión de los artículos, a partir de las bases de datos PubMed, Science Direct, Scopus, Google Scholar, etc, y en base a los criterios de inclusión, se seleccionaron informes de casos, cohortes y numerosos estudios clínicos utilizados en un periodo mayoritariamente de 4 años (2019-2023). La muestra final utilizada en esta revisión incluyó 120 artículos.

    Resultados y conclusiones: Los resultados mostraron que el DNI puede considerarse como un biomarcador primario y confiable para el diagnóstico, pronóstico, triaje inicial, resultados quirúrgicos, diversas infecciones, así como para predecir la gravedad de afecciones pediátricas y ginecológicas y trastornos cardiopulmonares o gastrointestinales y etc.

  • English

    Background: A brand-new biomarker for diagnosis and prognosis for a variety of inflammatory or infectious conditions is the delta neutrophil index (DNI). DNI is a laboratory index that is determined by dividing the total number of peripheral blood neutrophils by the number of immature granulocytes. However, there are few studies that have examined the potential use of DNI as a prognostic biomarker in gastrointestinal disorders and their associated infections. The purpose of this study was to explore the role of delta neutrophil index (DNI) as a biomarker to determine the prognosis of infectious conditions, especially in gastrointestinal diseases.

    Methods: The research is a bibliographic review. To review the articles, from the databases PubMed, Science Direct, Scopus, Google Scholar, etc., and based on the inclusion criteria, case reports, cohorts and numerous clinical studies used in a period of mostly 4 years (2019-2023) were selected. The final sample used in this review included 120 articles.

    Results and conclusion: The results showed that DNI may be considered as a primary and reliable biomarker for diagnosis, prognosis, initial triage, surgical outcomes, various infections, as well as predicting the severity of pediatric and gynecological conditions and cardiopulmonary or gastrointestinal disorders and etc.

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