Drug-Induced Stevens Johnson’s Syndrome; 4 case Series in Tertiary Hospital in Somalia

• Oznur Sari ^[1] ; Ahmed Muhammad Bashir ^[2]
  1. [1] Department of Internal Medicine, Department of Health Services, General Directorate of Public Hospitals, Ministry of Health, Ankara, Turkey
  2. [2] Department of Internal Medicine, Mogadishu Somalia Turkiye Training and Research Hospital, Mogadishu, Somalia
• Localización: Academic Journal of Health Sciences: Medicina Balear, ISSN-e 2255-0560, Vol. 38, Nº. 4, 2023, págs. 175-177
• Idioma: inglés
• DOI: 10.3306/AJHS.2023.38.04.175
• Títulos paralelos:
  • Síndrome de Stevens Johnson inducido por fármacos; serie de 4 casos en un hospital terciario de Somalia
• Enlaces
  • Texto completo (pdf)
• Resumen
  • español

    Una conocida reacción adversa cutánea grave (RAC) de tipo IV, mediada por un impacto inmunitario, es el síndrome de Stevens- Johnson/necrolisis epidérmica tóxica (SJS/TEN).

    En este artículo se presentan 4 casos de SJS en un hospital de tercer nivel de Mogadiscio (Somalia). El síndrome de Stevens- Johnson tiene una importante relación con diversos fármacos. El síndrome de Stevens-Johnson es una complicación terapéutica potencial, especialmente en Somalia, donde los antibióticos se utilizan de forma irracional. Los esteroides se utilizan de forma controvertida como tratamiento. El síndrome de Stevens-Johnson es más común en Somalia y otras partes de África porque los antibióticos están disponibles sin receta. Es difícil de detectar y manejar; la mayoría de los pacientes mueren antes de obtener un diagnóstico firme.

  • English

    Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a well-known severe cutaneous adverse reaction (SCAR) that belongs to type IV hypersensitivity and is mediated by an immunological effect.

    Here, we report 4 cases of SJS presented to a tertiary hospital in Mogadishu, Somalia. Stevens-Johnson syndrome has a significant relationship to various drugs. Stevens-Johnson syndrome is a potential therapeutic complication, especially in Somalia, where antibiotics are used irrationally. Steroids are controversially used as treatment. SJS is more common in Somalia and other parts of Africa because antibiotics are available without a prescription. It’s difficult to detect and manage; most patients die before a firm diagnosis is obtained.

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