Primaquina, gametocitemia de Plasmodium falciparum y bloqueo de transmisión: ineficacia del actual régimen de dosificación

• Carmona-Fonseca, Jaime ^[1] ; Arango Flórez, Eliana María ^[1]
  1. [1] Universidad de Antioquia

     Universidad de Antioquia

     Colombia

     
• Localización: MedUNAB, ISSN-e 2382-4603, ISSN 0123-7047, Vol. 15, Nº. 1, 2012 (Ejemplar dedicado a: Brain aneurysm, Diagnostic Images, Biological accidents.), págs. 14-21
• Idioma: español
• DOI: 10.29375/01237047.1641
• Enlaces
  • Texto completo
• Resumen

  • Antecedentes: Los esquizonticidas anti-Plasmodium falciparum reducen la gametocitemia, sin erradicarla; por ello, se adiciona primaquina (PQ). Esta se administra al terminar el esquizonticida: día 4; 0,75 mg/kg; dosis única (régimen estándar). Las artemisininas actúan sobre gametocitos inmaduros I-IV de P. falciparum; la PQ actúa sobre gametocitos maduros (estadio V). ¿Cuál es la eficacia antigametocitos de la combinación esquizonticida-PQ? Objetivo:Analizar la eficacia de PQ-régimen estándar contra gametocitos de P. falciparum, asociada al esquizonticida.

    Metodología: Revisión sistemática de los artículos hallados en Pubmed y Lilacs.

    Resultados y conclusiones: Ningún esquizonticida elimina totalmente los gametocitos en 6-7 días iniciales de tratamiento. La adición de PQ-régimen estándar tiene potente acción antigametocitos. Ninguna combinación esquizonticida-PQ tiene eficacia total en ese plazo. No conocemos cómo varía la eficacia antigametocitos de PQ dada los días 1 a 3, ni en dosis diferentes a la estándar, ni en múltiples dosis. [Carmona-Fonseca J, ,Arango EM. Primaquina,gametocitemia de Plasmodium falciparum y bloqueo de transmisión: ineficacia del actual régimen de dosificación. MedUNAB 2012;15:14-21].

• Referencias bibliográficas
  • .Alano P. Plasmodium falciparum gametocytes: still many secrets of a hidden life. Mol Microbiol 2007; 66: 291-302.
  • Carter R, Graves P. Gametocytes. In: Wernsdorfer W, McGregor S (ed). Malaria. Principles and practice of malariology. Edinburgh, London, Melbourne...
  • Fujioka H, Aikawa M. The malaria parasite and its life-cycle. In: Wahlgren M, Perlmann P(ed). Malaria molecular and clinical aspects. Amsterdam:...
  • Talman A, Dormarle O, McKenzie F, Ariey F, Robert V. Gametocytogenesis:thepubertyofPlasmodiumfalciparum. Malar J 2004;14(3):24.
  • Bousema T, Roeffen W, Meijerink H, Mwerinde H, Mwa-kalinga S, van Gemert G, et al. The dynamics of naturally acquired immune responses to...
  • Contreras-OchoaC,RamseyJ.GametocitosdePlasmodium vivax y Plasmodium falciparum: etapas relegadas en el desarrollo de vacunas. Salud Publ México...
  • Baker D. Malaria gametocytogenesis. Mol Biochem Pa-rasitol 2010;172:57-85.
  • Lawpoolsri S, Klein E, Singhasivanon P, Yimsamran S, Thanyavanich N, Maneeboonyang W, et al. Optimally timing primaquine treatment to reduce...
  • WHO Guidelines for the treatment of malaria. WHO/HTM/MAL/2006.1108. Geneva: World Health Organization,2006.
  • Tuteja R. Malaria: an overview. FEBS Journal 2007;274: 4670-9.
  • WHO. The use of antimalarial drugs. WHO/CDS/RBM/2001.33. Geneva: World Health Organization, 2001.
  • Butcher G. Antimalarial drugs and the mosquito transmission of plasmodium. Int J Parasitol 1997;27:975-87.
  • Bousema T, Sutherland C, Churcher T, Mulder B, Gouagna L, Riley E, et al. Human immune responses that reduce the transmission of Plasmodium...
  • Ouédraogo A, Bousema T, de Vlas S, Cuzin-Ouattara N, Verhave J, Drakeley C, et al. The plasticity of Plasmodium falciparum gametocytaemia...
  • Gogtay N, Kamtekar K, Dalvi S, Mehta S, Chogle A, Aigal U, et al. Arandomized, parallel study of the safety and efficacy of 45 mg primaquine...
  • Kshirsagar N. Malaria: anti malarial resistance and policy ramifications and challenges. J Postgrad Med, 2006;52:291-293.
  • Bukirwa H, Critchley J. Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated...
  • Carmona J, Arango E, Blair S. Gametocitemia en malaria por Plasmodium falciparum tratada con amodiaquina o artesunato. Iatreia 2008;18:5-26.
  • Osorio L, Gonzalez I, Olliaro P, Taylor W. Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia....
  • Shekalaghe S, Drakeley C, Gosling R, Ndaro A, van Meegeren M, Enevold A, et al. Primaquine clears submicroscopic Plasmodium falciparum gametocytes...
  • Tangpukdee N, Krudsood S, Srivilairit S, Phophak N, Chonsawat P, Yanpanich W, et al. Gametocyte clearance in uncomplicated and severe Plasmodium...
  • Wilairatana P, Krudsood S, Tangpukdee N. Appropriate time for primaquine treatment to reduce Plasmodium falciparum transmission in hypoendemic...
  • Wilairatana P, Tangpukdee N, Krudsood S. Long term primaquine administration to reduce Plasmodium falciparum gametocyte transmission in hypoendemic...
  • Peatey C, Skinner-Adams T, Dixon M, McCarthy J, Gardiner D, Trenholme K. Effect of antimalarial drugs on Plasmodium falciparum gametocytes....
  • Tanaka T, Williamson K. A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue. Mol Biochem Parasitol 2011;177:160-163.
  • Vale N, Moreira R, Gomes P. Primaquine revisited six decades after its discovery. Europ J Med Chem 2009;44:937-53.
  • White N. The role of anti-malarial drugs in eliminating malaria. Malar J 2008;7(Suppl 1):S8.
  • Chotivanich K, Sattabongkot J, Udomsangpetch R, Looareesuwan S, Day N, Coleman R, et al. Transmission-blocking activities of nts Chemother...
  • Gogtay NJ, Kamtekar KD, Dalvi SS, Mehta SS, Chogle AR, Aigal U, Kshirsagar NA. A randomized, parallel study of the safety and efficacy of...
  • Kamtekar K, Gogtay N, Dalvi S, Karnad D, Chogle A, Aigal U, et al. A prospective study evaluating the efficacy of a single 45 mg dose of primaquine...
  • Kaneko A, Kamei K, Suzuki T, Ishii A, Siagian R, Panjaitan W. Gametocytocidal effect of primaquine in chemotherapeutic malaria control trial...
  • Singhasivanon V, Chongsuphajaisiddhi T, Sabchareon A, Attanath P, Webster H, Edstein M, et al. Pharmacokinetic study of mefloquine in Thai...
  • Smithuis F, Kyaw M, Phe O, Win T, Aung P, Phyo Oo A, et al. Effectiveness of five artemisinin combination regimens with or without primaquine...
  • Vásquez A, Sanín F, Alvarez L, Tobón A, Ríos A, Blair S. Estudio piloto de la eficacia y de los efectos sobre los gametocitos del esquema...
  • Bousema T, Okell L, Shekalaghe S, Griffin J, Omar S, Sawa P, et al. Revisiting the circulation time of Plasmodium falciparum gametocytes:...
  • Carmona-Fonseca J. Tratamientos para malaria basados en artemisininas: Revisión general y notas sobre su uso en Colombia. Medellín: “Grupo...
  • Okell L, Drakeley C, Ghani A, Bousema T, Sutherland C. Reduction of transmission from malaria patients by artemisinin combination therapies:...
  • Schneider P, Bousema T, Omar S, Gouagna L, Sawa P, Schallig H, et al. (Sub) microscopic P. falciparum gametocytaemia in Kenyan children after...
  • Ouédraogo A, Bousema T, Schneider P, de Vlas S, Ilboudo-Sanogo E, Cuzin-Ouattara N, et al. Substantial contribution of submicroscopical Plasmodium...
  • Chen P, Li G, Guo X, He K, Fu Y, Fu L, et al. The infectivity of gametocytes of Plasmodium falciparumfrom patients treated with artemisinin....
  • Chomcharn Y, Surathin K, Bunnag D, Sucharit S, Hari-nasuta T. Effect of a single dose of primaquine on a Thai strain of Plasmodium falciparum....
  • Barnes K, Little F, Mabuza A, Mngomezulu N, Govere J, Durrheim D, et al. Increased gametocytemia after treatment: an early parasitological...
  • Arango E, Upegui Y, Carmona-Fonseca J. Efficacy of different primaquine based antimalarial schemes against Plasmodium falciparum gametocytemia....
  • Alving A, Arnold J, Hockwald R, Clayman C, Dern R, Beutler E, et al. Potentiation of the curative action of primaquine in vivax malaria by...
  • Bray P, Deed S, Fox E, Kalkanidis M, Mungthin M, Deady L, et al. Primaquine synergises the activity of chloroquine against chloroquine-resistant...
  • Edgcomb J, Arnold J, Yount EJ, Alving A, Eichelberger L, Jeffery G, et al. Primaquine, SN 13272, a new curative agent in vivax malaria; a...
  • El-Sayed B, El-Zaki S, Babiker H, Gadalla N, Ageep T, Mansour F, et al. A randomized open-label trial of artesunate-sulfadoxine-pyrimethamine...
  • Lederman E, Maguire J, Sumawinata I, Chand K, Elyazar I, Estiana L, et al. Combined chloroquine, sulfadoxine/ pyrimethamine and primaquine...
  • Pukrittayakamee S, Chotivanich K, Chantra A, Clemens R, Looareesuwan S, White N. Activities of artesunate and primaquine against asexual-...
  • Suputtamongkol Y, Chindarat S, Silpasakorn S, Chaika-chonpatd S, Lim K, Chanthapakajee K, et al. The efficacy of combined mefloquine-artesunate...
  • Pukrittayakamee S, Imwong M, Looareesuwan S, White N. Therapeutic response to antimalarial and antibacterial drugs in vivax malaria. Acta...
  • Pukrittayakamee S, Vanijanonta S, Chantra A, Clemens R, White N. Blood stage antimalarial efficacy of primaquine in Plasmodium vivax malaria....
  • WHO. Guidelines for the treatment of malaria. Geneva: World Health Organization, 2 ed,2010.
  • Arango E, Alvarez T, Carmona J, Blair S. Gametocitemia de Plamodium falciparum según la respuesta terapeutica a sulfadoxinapirimetamina y...
  • Osorio L, Ferrero B, Castillo C. Effects of choloquine and slfadoxine/pyrimethamine on gametocytes in patients with uncomplicated Plasmodium...
  • Blair S, Carmona-Fonseca J, Piñeros J, Ríos A, Álvarez T, Álvarez G,et al. Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia....