Role of cardiorespiratory fitness on the associations between endocannabinoid system and depressive symptoms in adults diagnosed with depression: the SONRIE study

• M. Ruiz-Muñoz ^[1] ; S. Ortega-Gómez ^[1] ; D. Jiménez-Pavón ^[1] ; M.M. Espinosa-Nogales ^[2] ; M.A. Rosety-Rodríguez ^[1] ; V. España-Romero ^[1]
  1. [1] University of Cádiz, Puerta del Mar University Hospital
  2. [2] Puerto Real University Hospital
• Localización: Revista andaluza de medicina del deporte, ISSN 1888-7546, Vol. 15, Nº. 3, 2022, págs. 93-96
• Idioma: inglés
• Títulos paralelos:
  • Papel de la capacidad cardiorrespiratoria en la asociación entre el sistema endocannabinoide y los síntomasdepresivos en adultos diagnosticados de depresión: el estudio SONRIE
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• Resumen
  • español

    Objetivo: El sistema endocannabinoide (SE) parece estar alterado en pacientes con depresión. La capacidad cardiorrespiratoria (CRF) puede ser un factor que interactúe en la relación entre los biomarcadores del SE y los síntomas depresivos en personas diagnosticadas de depresión. El objetivo de este trabajo es estudiar el papel del CRF en la posible asociación entre los biomarcadores de ES y los síntomas depresivos en 73 adultos diagnosticados de depresión. Método: Este estudio examina los resultados de la aptitud cardiorrespiratoria y los niveles plasmáticos de los mediadores lipídicos; anandamida (AEA) y 2-araquidoilglicerol (2-AG) en 73 adultos diagnosticados de depresión.Resultados: Los pacientes con alto nivel de CRF tuvieron una asociación significativa e inversa entre los síntomas depresivos y los niveles séricos de 2-AG ( : -0,013; IC 95%: -0,262 a -0,000; R²=22,6; P<0,001). β: -0.013; 95% CI: -Conclusiones: Los niveles más altos de CRF podrían tener un papel protector sobre los síntomas depresivos por el aumento de 2-AG.

  • English

    Objective: Endocannabinoid system (ES) seems to be altered in patients with depression. Cardiorespiratory fitness (CRF) may be an interacting factor inthe relationship between ES biomarkers and depressive symptoms in people diagnosed with depression. The aim was to study the role of CRF on thepossible association between ES biomarkers and depressive symptoms in 73 adults diagnosed with depression. Method: This study examine the outcomes of cardiorespiratory fitness and plasma levels of the lipid mediators; anandamide (AEA) and 2-arachidonoylglycerol (2-AG) sampled from 73 adults diagnosed with depression.Results: Patients with high CRF level had significant and inverse association among depressive symptoms and 2-AG serum levels ( : -0.013; 95% CI: -β: -0.013; 95% CI: -0.262 to -0.000; R²=22.6; P<0.001).Conclusions: Higher CRF levels could have a protective role on depressive symptoms by increases in 2-AG.

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