Vitamin D has no significant associations with high sensitivity C reactive protein and tumor necrosis factor-alpha in adults with prediabetes

• Ibrahim Faisal ^[1] ; Shahed Morshed ^[3] ; Tahniyah Haq ^[2] ; Shahjada Selim ^[2] ; Md Habibul Ghani ^[4] ; Muhammad Abul Hasanat ^[2] ; Md Fariduddin ^[2]
  1. [1] Indira Gandhi Memorial Hospital

     Indira Gandhi Memorial Hospital

     Maldivas

     
  2. [2] Bangabandhu Sheikh Mujib Medical University

     Bangabandhu Sheikh Mujib Medical University

     DCC (Kotwali), Bangladés

     
  3. [3] Emergency Medical Officer, Kurmitola General Hospital, Dhaka, Bangladesh
  4. [4] Junior Consultant, Jinjira 20 beded Hospital, Keranigonj, Dhaka, Bangladesh

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• Localización: Academic Journal of Health Sciences: Medicina Balear, ISSN-e 2255-0560, Vol. 38, Nº. 3, 2023, págs. 137-141
• Idioma: inglés
• DOI: 10.3306/AJHS.2023.38.03.137
• Títulos paralelos:
  • La vitamina D no tiene asociaciones significativas con la proteína C reactiva de alta sensibilidad y el factor de necrosis tumoral alfa en adultos con prediabetes
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• Resumen
  • español

    Objetivo: Tanto la deficiencia de vitamina D (VDD) como la metainflamación son comunes en pacientes con prediabetes. El objetivo de este estudio fue ver la asociación de la vitamina D con los marcadores inflamatorios: proteína C reactiva de alta sensibilidad (hs-CRP) y factor de necrosis tumoral-alfa (TNF-α) en adultos con prediabetes.

    Métodos: Este estudio transversal incluyó a 115 adultos recién detectados con prediabetes [edad (años): 36,37±10,06, m/f:

    23/92, IMC (kg/m2): 28,81±4,34]. Se recogió información clínica y se extrajo sangre en ayunas para medir la vitamina D por cromatografía líquida de alto rendimiento, la hs-CRP por turbidimetría/inmunoturbidimetría y el TNF-α por el método ELISA.

    Resultados: Alrededor del 46,09% tenía VDD (<20 ng/mL), el 33,04% tenía insuficiencia de vitamina D (20-29,9 ng/mL) y el 60,87% tenía alto riesgo cardiovascular (hs-CRP ≥3,0 mg/L) y el 92,17% tenía un estado inflamatorio alto (TNF-α ≥2,53 pg/ mL). Tanto los niveles de hs-CRP como de TNF-α no mostraron diferencias estadísticamente significativas según el estado de la vitamina D. Los análisis de regresión mostraron que tanto la hs-CRP como el TNF-α no tenían asociaciones predictivas con el nivel o el estado de la vitamina D en adultos con prediabetes (NS para ambos).

    Conclusión: La vitamina D no tuvo una asociación significativa con la PCR-as y el TNF-α en adultos con prediabetes.

  • English

    Objective: Both vitamin D deficiency (VDD) and meta-inflammation are common in patients with prediabetes. The aim of this study was to see the association of vitamin D with inflammatory markers: high-sensitivity C reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-α) in adults with prediabetes.

    Methods: This cross-sectional study included 115 newly detected adults with prediabetes [age (years): 36.37±10.06, m/f: 23/92, BMI (kg/m2): 28.81±4.34]. Clinical information was collected and blood was taken in a fasting state to measure vitamin D by highperformance liquid chromatography, hs-CRP by turbidimetric/immunoturbidimetric, and TNF-α by ELISA method.

    Results: About 46.09% had VDD (<20 ng/mL), 33.04% had vitamin D insufficiency (20-29.9 ng/mL) and 60.87% had high cardiovascular risk (hs-CRP ≥3.0 mg/L) and 92.17% had high inflammatory status (TNF-α ≥2.53 pg/mL). Both hs-CRP and TNF-α levels were statistically similar across the vitamin D status (NS for both). Regression analyses showed that both hs-CRP and TNF-α had no predictive associations with either vitamin D level or status in adults with prediabetes (NS for both).

    Conclusion: Vitamin D had no significant association with hs-CRP and TNF-α in adults with prediabetes.

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