Prevalence of prediabetes among first degree relatives of type 2 diabetes individuals in Abakaliki, Ebonyi State Nigeria

• Innocent Sidney Ikechi ^{[1] [3]} ; Ezinne Jane Ejike-Odeh ^[1] ; Onwe Emmanuel Ifeanyichukwu ^[1] ; Chinemerem Ogbu ^[3] ; Ude Ugomma Agwu ^[1] ; Emmanuel Ifeanyi Obeagu ^[2]
  1. [1] Ebonyi State University

     Ebonyi State University

     Nigeria

     
  2. [2] Kampala International University

     Kampala International University

     Kampala Capital City, Uganda

     
  3. [3] Department of Medical Laboratory Science, Evangel University. Akaeze. Ebonyi State Nigeria.

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• Localización: Academic Journal of Health Sciences: Medicina Balear, ISSN-e 2255-0560, Vol. 38, Nº. 2, 2023, págs. 85-88
• Idioma: inglés
• DOI: 10.3306/AJHS.2023.38.02.85
• Títulos paralelos:
  • Prevalencia de prediabetes entre familiares de primer grado de personas con diabetes tipo 2 en Abakaliki, Estado de Ebonyi, Nigeria
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• Resumen
  • español

    Objetivo: El objetivo de este estudio era determinar la prevalencia y los factores de la prediabetes (PD) entre los familiares de primer grado (FDR) de los sujetos con diabetes tipo 2 (T2D) en la metrópolis de Abakaliki, estado de Ebonyi, Nigeria.

    Material y métodos: Se seleccionaron 100 participantes (70 hombres y 30 mujeres) mediante un muestreo dirigido por los encuestados y se les entrevistó sobre sus conocimientos, síntomas comunes e historia familiar de la T2D. Se recogieron muestras de sangre venosa después de un ayuno nocturno y 2 horas después de una dosis oral de 75g de glucosa anhidra. Las muestras se recogieron en frascos de oxalato de flúor, se mantuvieron a 40C y se analizaron en la hora siguiente a la recogida por el método de la glucosa oxidasa. Los datos se analizaron con el programa SPSS 20.0 y se resumieron como media y desviación estándar.

    Resultados: Veintidós FDR (17 hombres y 5 mujeres) tenían EP, lo que arroja unas tasas de prevalencia del 22%, 24,3% y 16,7%, respectivamente, para la totalidad de la población del estudio, los hombres y las mujeres. 13 (11 hombres y 2 mujeres; 84,6% y 6,7%) de los FDR con EP tenían sólo IFG, mientras que 3 (4,3 y 10% respectivamente) tenían sólo ATG. Sólo 3 varones (4,3%) tenían tanto IFG como ATG. El IMC de los sujetos con ATG (23,80 ± 2,68 kg/m2) fue significativamente mayor que el de los sujetos con ATG (22,09 ± 1,94 kg/m2) (p = 0,028). Los sujetos femeninos con EP tenían un IMC significativamente mayor (21,8 ± 3,38 vs 21,73 ± 3,15 kg/m2; p = 0,035) que los FDR masculinos. Casi el 25% de los sujetos FDR de T2D en Abakaliki tienen EP y están en riesgo de desarrollar diabetes.

    Conclusiones: Hay más hombres que mujeres afectados. La masa corporal, entre otros, puede ser un factor contribuyente.

  • English

    Aim: This study was aimed at determining the prevalence and factors of pre-diabetes (PD) among first degree relatives, (FDRs) of type 2 diabetes, (T2D) subjects in Abakaliki Metropolis, Ebonyi State, Nigeria.

    Methods: 100 participants (70 men and 30 women) were selected through respondent-driven sampling and interviewed about their knowledge, common symptoms and family history of T2D. Venous blood samples were collected after an overnight fast and 2 hours after a 75g oral dose of 75g anhydrous glucose. Samples were collected into fluoride-oxalate bottles, kept at 40ºC and analyzed within 1 hour of collection by the glucose oxidase method. Data were analyzed using SPSS 20.0 and summarized as mean and standard deviation.

    Results: Twenty-two FDRs – (17 male and 5 females) had PD giving prevalence rates of 22%, 24.3% and 16.7% respectively for the entire study, males and females populations respectively. 13 (11 male, 2 females; 84.6% and 6.7%) of FDRs with PD had IFG only while 3 each – (4.3 and 10% respectively) - had IGT only. 3 males only (4.3%) had both IFG and IGT. The BMI of subjects with IGT (23.80 ± 2.68 kg/m2) was significantly higher than IFG (22.09 ± 1.94 kg/m2) (p = 0.028). Female subjects with PD had significantly higher BMI (21.8 ± 3.38 vs 21.73 ± 3.15 kg/m2; p = 0.035) than the male FDRs. Almost 25% of FDRs of T2D subjects in Abakaliki have PD and are at risk of developing diabetes.

    Conclusion: More men than women were affected. Body mass, among others, may be a contributing factor.

• Referencias bibliográficas
  • American Diabetes Association Standards of medical care in diabetes. Classification and diagnosis of diabetes. 2016.
  • American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;...
  • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardio-vascular causes. N Engl J Med.2007; 356(24):...
  • Yaturu S. Prediabetes Progression to Diabetes among Veterans. Journal of Diabetes Mellitus. 2020; 10, 202-7.
  • Gombet T, Longo-Mbenza B, Ellenga-Mbolla B, Ikama MS, Kimbally-Kaki G, Nkoua JL, et al. Prevalence rates and cardiometabolic determinants...
  • DeFronzo RA, Abdul-Ghani MA. Preservation of bet cell function: the key to diabetes prevention. J Clin Endocrionol Metab. 2009; 96(8):2354-66.
  • Clark A. Pancreatic Islet Pathology in type 2 diabetes in Pancreatic Beta Cell in Health and Disease Seino, S. Bell, G. J, ed Springer, New...
  • Basu A, Pedsersen MG, Cobelli C. Commentary. Pre-diabetes: evaluation of beta-cell function. Diabetes. 2012; 61(2):270-1.
  • Ranlo-Halsted BA, Edelman SV. The natural history of type 2 diabetes: implications for clinical practice. Primary care. 2011; 26(4): 771-89.
  • Filippini T, Wise LA, Vinceti M. Cadmium exposure and risk of diabetes and prediabetes: A systematic review and dose-response meta-analysis. Environ...
  • Cochram WG. Sampling techniques. 3rd Ed. New York. John Wiley & Sons.1977;
  • Cheesbrough M. District Laboratory Practice in Tropical Countries. Part 1. Second Edition Cambrdge University Press. 2009; Pp 340-9
  • Ezeala-Adikaibe B, Mbadiwe N, Okwara C, Onodugo O, Onyekonwu C, Ijoma U, et al. Diabetes and Pre-Diabetes among Adults in an Urban Slum in South...
  • Olatunbosun ST, Ojo PO, Fineberg N, Bella AF. Prevalence diabetes mellitus and impaired glucose tolerance in a group of urban adults in Nigeria....
  • Gerstein HC, Santaguida P, Raina P, Morrison KM, Balion C, Hunt D, Yazdi H, Booker L. Annual incidence and relative risk of diabetes in people...
  • Ogbu ISI, Azodo EC, Chinwuba AU .Prevalence of prediabetes and unreported diabetes mellitus in a population aged 45 years and above in Owerri...
  • Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, Kochba I, Rudich A; Israeli Diabetes Research Group. Normal fasting plasma glucose...
  • Perreault L, Pan Q, Mather KJ, Watson KE, Hamman RF, Kahn SE; Diabetes Prevention Program Research Group. Effect of regression from prediabetes...
  • Weir GC, Bonner-Weir S. Five stages of evolving β – cell dysfunction during progression to diabetes. Diabetes 2004; 2: 97-113
  • Levitan EB, Song Y, Fotd ES, Liu S. Is non-diabetes hyperglycaemia a risk factor for cardio-vascular disease? A meta-analysis of prospective...
  • Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol...
  • Afifi Raouf M, Saad AE, Al Shehri A. Prevalence and Correlates of Prediabetes and Diabetes Results-I: A Screening Plan in a Selected Military Community...
  • Trolice, M. Defining prediabetes in polycystic ovarian syndrome. Open Journal of Obstetrics and Gynecology 2011; 1, 36-41.
  • Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL. Clinical factors associated with resistance to...