Recomendaciones del uso de antimicrobianos en heridas crónicas

Angel Romero Collado; José Verdú Soriano; Erica Homs Romero

Recomendaciones del uso de antimicrobianos en heridas crónicas

Ángel Romero Collado ^[1] ; José Verdú Soriano ^[2] ; Erica Homs Romero ^[2]
1. [1] Universitat de Girona
  
  Universitat de Girona
  
  Gerona, España
2. [2] Universitat d'Alacant
  
  Universitat d'Alacant
  
  Alicante, España
Localización: Gerokomos: Revista de la Sociedad Española de Enfermería Geriátrica y Gerontológica, ISSN 1134-928X, Vol. 33, Nº. 2, 2022, págs. 111-118
Idioma: español
Títulos paralelos:
- Recommendations on the application of antimicrobials in chronic wounds
Enlaces
- Texto completo
Resumen
- español
  RESUMEN En este artículo, basado en el documento técnico n.º VIII del GNEAUPP, se actualizan algunos conceptos relacionados con los antimicrobianos y se añaden nuevas herramientas terapéuticas para prevenir y luchar frente a uno de los factores más importantes que impiden que cicatrice una herida: los problemas relacionados con los microorganismos, clásicamente la infección y, ahora, también el impacto de los biofilms. Se asume el sistema propio del GNEAUPP de gradación de la evidencia, que clasifica la fuerza de la recomendación en alta, moderada o baja. Los antimicrobianos analizados mediante su modo de actuación, presentación comercial, recomendaciones de uso, contraindicaciones y efectividad sobre el biofilm son: el alcohol, la clorhexidina, el hipoclorito sódico, la octenidina, la plata y los yodóforos. También los efectos de los llamados agentes antibiofilm, aunque la mayoría se han realizado in vitro. Para finalizar, se realizan una serie de recomendaciones dirigidas a los investigadores para generar nuevas evidencias relacionadas con los antimicrobianos y su aplicabilidad clínica.
- English
  ABSTRACT This article, based on GNEAUPP Technical Paper No. VIII, updates some concepts related to antimicrobials and adds new therapeutic tools to prevent and fight against one of the most important factors that prevent wound healing: problems related to microorganisms, classically infection and now also the impact of biofilms. The GNEAUPP's own evidence grading system is used, which classifies the strength of the recommendation as high, moderate or low. The antimicrobials analyzed in terms of their mode of action, commercial presentation, recommendations for use, contraindications and effectiveness on biofilm are: alcohol, chlorhexidine, sodium hypochlorite, octenidine, silver and iodophors. Also the effects of the so-called antibiofilm agents, although most of them have been performed in vitro. Finally, a series of recommendations are made to researchers to generate new evidence related to antimicrobials and their clinical applicability.
Referencias bibliográficas
- Blanco Blanco, J,Blasco García, C,Ballesté Torralba, J,Casamada Humet, N,García González, F,Gago Fornells, M. (2002). Recomendaciones sobre...
- López-Casanova, P,Pancorbo-Hidalgo, PL,Verdú-Soriano, J,Rodríguez-Palma, M,Soldevilla-Ágreda, JJ,García-Fernández, F. (2020). Qué no hacer...
- Verdú Soriano, J,López-Casanova, P,Sánchez Romero, I,Segovia Gómez, T. (2018). Toma de muestras para el laboratorio de microbiología. Procedimientos...
- (2016). International Wound Infection Institute (IWII) Wound infection in clinical practice. Wounds International. London.
- Zapata-Sampedro, M,Zambrano Muñoz, M,Castro Varela, L. (2012). Colonización crítica. Una revisión de evidencias. Enferm Docente. 98. 26-34
- Dissemond, J,Strohal, R,Mastronicola, D,Senneville, E,Moisan, C,Edward-Jones, V. (2020). Therapeutic Index for Local Infections score validity:...
- Dissemond, J,Gerber, V,Lobmann, R,Kramer, A,Mastronicola, D,Senneville, E. (2020). Therapeutic index for local infections score (TILI): A...
- Rahim, K,Saleha, S,Zhu, X,Huo, L,Basit, A,Franco, OL. (2017). Bacterial Contribution in Chronicity of Wounds. Microb Ecol. 73. 710
- Malone, M,Bjarnsholt, T,McBain, AJ,James, GA,Stoodley, P,Leaper, D. (2017). The prevalence of biofilms in chronic wounds: A systematic review...
- Dowd, SE,Wolcott, RD,Kennedy, J,Jones, C,Cox, SB. (2011). Molecular diagnostics and personalised medicine in wound care: Assessment of outcomes....
- (2016). World Union of Wound Healing Societes (WUWHS) Management of Biofilm. Wounds International. London.
- García-Fernández, FP,Pancorbo-Hidaldo, PL,Soldevilla-Ágreda, JJ,Verdú Soriano, J,López-Casanova, P,Rodríguez-Palma, M. (2018). Manejo Local...
- Schultz, G,Bjarnsholt, T,James, GA,Leaper, DJ,McBain, AJ,Malone, M. (2017). Consensus guidelines for the identification and treatment of biofilms...
- Percival, SL,Cooper, RA,Lipsky, BA. (2010). Microbiology of wounds. CRC Press. Boca Raton (Florida).
- Romero-Collado, A,Raurell-Torreda, M,Zabaleta-del-Olmo, E,Homs-Romero, E,Bertran-Noguer, C. (2015). Course Content Related to Chronic Wounds...
- Lipsky, BA,Dryden, M,Gottrup, F,Nathwani, D,Seaton, RA,Stryja, J. (2016). Antimicrobial stewardship in wound care: a Position Paper from the...
- Ousey, K. (2018). The role of topical metronidazole in management of infected wounds. Wounds UK. 14. 105
- Bowler, PG. (2018). Antibiotic resistance and biofilm tolerance: A combined threat in the treatment of chronic infections. J Wound Care. 27....
- Roberts, CD,Leaper, DJ,Assadian, O. (2017). The Role of Topical Antiseptic Agents Within Antimicrobial Stewardship Strategies for Prevention...
- Kramer, A,Dissemond, J,Kim, S,Willy, C,Mayer, D,Papke, R. (2018). Consensus on Wound Antisepsis: Update 2018. Skin Pharmacol Physiol. 31....
- Norman, G,Christie, J,Liu, Z,Westby, MJ,Jefferies, JM,Hudson, T. (2017). Antiseptics for burns. Cochrane Database Syst Rev.
- (2015). World Health Organization Global Action Plan on Antimicrobial Resistance. WHO Documents Production Services. Genève.
- Dumville, JC,Lipsky, BA,Hoey, C,Cruciani, M,Fiscon, M,Xia, J. (2017). Topical antimicrobial agents for treating foot ulcers in people with...
- Diomedi, A,Chacón, E,Delpiano, L,Hervé, B,Jemenao, MI,Medel, M. (2017). Antisépticos y desinfectantes. apuntando al uso racional. Recomendaciones...
- McDonell, G,Russell, AD. (1999). Antiseptics and Disinfectants: Activity, Action, and Resistance. Clin Microbiol Rev. 12. 147
- Williamson, DA,Carter, GP,Howden, BP. (2017). Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance...
- Webster, J,Osborne, S. (2015). Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database...
- Navarro Gracia, JF. (2016). Proyecto Infección Quirúrgica Zero. Sociedad Española de Medicina Preventiva, Salud Pública e Higiene. Pamplona....
- (2016). World Health Organization Global guidelines for the prevention of surgical site infection. WHO Documents Production Sevices. Genève....
- Stryja, J,Sandy-Hodgetts, K,Collier, M,Moser, C,Ousey, K,Probst, S. (2020). Surgical site infection: presenting and managing surgical site...
- Ban, KA,Minei, JP,Laronga, C,Harbrecht, BG,Jensen, EH,Fry, DE. (2017). American College of Surgeons and Surgical Infection Society: Surgical...
- Shen, Y,Stojicic, S,Haapasalo, M. (2011). Antimicrobial efficacy of chlorhexidine against bacteria in biofilms at different stages of development....
- Bonez, PC,Santos Alves, CF dos,Dalmolin, TV,Agertt, VA,Mizdal, CR,Flores, VDC. (2013). Chlorhexidine activity against bacterial biofilms....
- Stojicic, S,Shen, Y,Haapasalo, M. (2013). Effect of the source of biofilm bacteria, level of biofilm maturation, and type of disinfecting...
- Inoue, Y,Endo, S,Kondo, K,Ito, H,Omori, H,Saito, K. (1997). Trial of electrolyzed strong acid aqueous solution lavage in the treatment of...
- Garg, PK,Kumar, A,Sharda, VK,Saini, A,Garg, A,Shandu, A. (2013). Evaluation of intraoperative peritoneal lavage with super-oxidized solution...
- Allie, DE. (2006). Super-Oxideized Microcyn Technology in Lower-Extremity Wounds. Wounds A Compend Clin Res Pract. 18. 3-6
- Wolvos, TA. (2006). Advanced Wound care with Stable, Super-Oxidized Water. Wounds A Compend Clin Res Pract. 18. 11
- Hübner, NO,Siebert, J,Kramer, A. (2010). Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol...
- Radu, CA,Gazyakan, E,Germann, G,Riedel, K,Reichenberger, M,Ryssel, H. (2011). Optimizing Suprathel(r)-therapy by the use of Octenidine-Gel(r)....
- Sibbald, RG,Elliott, JA,Verma, L,Brandon, A,Persaud, R,Ayello, EA. (2017). Update: Topical Antimicrobial Agents for Chronic Wounds. Adv Ski...
- Kedziora, A,Speruda, M,Krzyzewska, E,Rybka, J,Lukowiak, A,Bugla-Ploskonska, G. (2018). Similarities and differences between silver ions and...
- Lo, SF,Hayter, M,Chang, CJ,Hu, WY,Lee, LL. (2008). A systematic review of silver-releasing dressings in the management of infected chronic...
- Adderley, U,Holt, I. (2014). Topical agents and dressings for fungating wounds. Cochrane Database Syst Rev.
- O'Meara, S,Al-Kurdi, D,Ologun, Y,Ovington, LG,Martyn-St James, M,Richardson, R. (2014). Antibiotics and antiseptics for venous leg ulcers....
- Chindera, K,Mahato, M,Kumar Sharma, A,Horsley, H,Kloc-Muniak, K,Kamaruzzaman, NF. (2016). The antimicrobial polymer PHMB enters cells and...
- Norman, G,Dumville, JC,Moore, ZEH,Tanner, J,Christie, J. (2016). Antibiotics and antiseptics for pressure ulcers. Cochrane Database Syst Rev....
- To, E,Dyck, R,Gerber, S,Kadavil, S,Woo, KY. (2016). The Effectiveness of Topical Polyhexamethylene Biguanide (PHMB) Agents for the Treatment...
- Bigliardi, PL,Alsagoff, SAL,El-Kafrawi, HY,Pyon, JK,Wa, CTC,Villa, MA. (2017). Povidone iodine in wound healing: A review of current concepts...
- Woo, K,Dowsett, C,Costa, B,Ebohon, S,Woodmansey, EJ,Malone, M. (2021). Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic...
- Angel, D,Morey, P,Storer, J,Mwipatayi, B. (2008). The great debate over iodine in wound care continues: a review of the literature. Wound...
- Kamiya, H,Ehara, T,Matsumoto, T. (2012). Inhibitory effects of lactoferrin on biofilm formation in clinical isolates of Pseudomonas aeruginosa....
- Ammons, MC,Copié, V. (2013). Mini-review: Lactoferrin: a bioinspired, anti-biofilm therapeutic. Biofouling. 29. 443
- Anjum, A,Sim, CH,Ng, SF. (2018). Hydrogels Containing Antibiofilm and Antimicrobial Agents Beneficial for Biofilm-Associated Wound Infection:...
- Percival, SL,Salisbury, AM. (2018). The efficacy of tetrasodium EDTA on biofilms. Adv Exp Med Biol. 1057. 101