Possible etiological role of Ezrin and Moesin in progression of breast cancer in Iraqi woman

• Mariam Qassim Al-Dulemey ^[1] ; Hazima Mossa Alabassi ^[1]
  1. [1] Department of Biology, collage of Education Ibn Al-Haitham ,University of Baghdad ,Iraq
• Localización: Academic Journal of Health Sciences: Medicina Balear, ISSN-e 2255-0560, Vol. 37, Nº. 6, 2022, págs. 94-99
• Idioma: inglés
• DOI: 10.3306/AJHS.2022.37.06.94
• Títulos paralelos:
  • Posible papel etiológico de Ezrin y Moesin en la progresión del cáncer de mama en la mujer iraquí
• Enlaces
  • Texto completo (pdf)
• Resumen
  • español

    Antecedentes: El cáncer de mama (CB) es la neoplasia maligna más frecuente en las mujeres y la segunda causa de muerte por cáncer en Irak. Métodos: Se realizó un estudio de casos y controles para evaluar el papel de Moesin y Ezrin en la patogenicidad del cáncer de mama en mujeres iraquíes. El estudio incluyó a 50 pacientes con CB emparejados por edad con 50 individuos sanos que sirvieron de grupo de control. Las concentraciones de Moesin y Ezrin se determinaron mediante la técnica de ensayo inmunoenzimático (ELISA). Resultados: Los resultados mostraron que hubo un aumento significativo del nivel sérico de Ezrin y Moesin en los pacientes frente al grupo de control y hubo una diferencia significativa en el suero de ambas moléculas adheridas en relación con el grupo de edad de los dos grupos estudiados. Sin embargo, no hay diferencias significativas entre el nivel sérico de (EZ andMO) con el grado y el estadio de la enfermedad. Conclusión: De acuerdo con los resultados actuales, la Ezrina y la Moesina pueden desempeñar un papel en la agresividad de las enfermedades, por lo que pueden considerarse una buena diana terapéutica para reducir la agresividad de la enfermedad.

  • English

    Background: Breast cancer (BC) is the most common malignancy in women and the second greatest cause of cancer death in Iraq (BC) reported the first type of cancer. Methods: A case-control study was conducted to assess the role of Moesin and Ezrin in pathogenicity of breast cancer in Iraqi women. The study included 50 patients with BC age matched with 50 healthy individuals served as a control group. The Moesin and Ezrin concentrations were determined by enzyme-linked immunosorbent assay (ELISA) technique. Results: The result showed that there was a significant increasing in Ezrin and Moesin serum level in Patients Versus control and there was significant difference in both adherent molecule serum as related with age group of the two under studied groups. But there is no significant difference between serum level of (EZ andMO) with grade and stage of disease. Conclusion: According to the current result, Ezrin and Moesin may has a role in the aggressiveness of diseases, so it may consider a good therapeutic target to reduce the aggressiveness of disease.

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