Déficit de Vitamina B12, demencia y Trastorno depresivo en población diabética mayor de 60 años

• Maria Luisa Lozano del Hoyo ^[1]
  1. [1] Enfermera, Centro de Salud Las Fuentes Norte. Zaragoza (Aragón), España
• Localización: Presencia: Salud mental, investigación y humanidades, ISSN-e 1885-0219, Nº. 13, 2017
• Idioma: español
• Títulos paralelos:
  • Vitamine B12 deficit, dementia and dpresive disorder in diabetic population over 60
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• Resumen
  • español

    Objetivo principal: Evaluar el diagnóstico de déficit de vitamina B12, trastorno depresivo y demencia en diabéticos tipo 2 mayores de 60 años. Metodología: Diseño descriptivo trasversal. Resultados principales: Hay un 30'3% de pacientes con diagnóstico de trastorno depresivo, 9'1% con demencia y 7'4% con déficit de vitamina B12. La media de años tomando metformina es de 3,9±4,4, dosis media 1'7± 0'6 mg. El riesgo de déficit de Vitamina B12 se multiplica por 1'8 si es hombre (RR=1'4). Las tres patologías tienen en común más de 4 años de diagnóstico y obesidad. El déficit de vitamina B12 y el Trastorno depresivo coinciden en la edad. No se pide vitamina B12 en el 91'3% de los pacientes. Se definen tres pacientes reto a identificar en consulta de enfermería. Conclusión principal: Hay infra diagnóstico de las tres patologías asociadas.

  • English

    Objective: Evaluaring the diagnosis of vitamin B12 deficit, depressive disorder and dementia in diabetic tipe 2 over 60. Methods: Cross-sectional design. Results: There is 30'3% of patients diagnosed with depressive disorder, 9'1% with dementia and 7'4% with vitamin B12 deficit. The average of the years taking metformine is 3,9±4,4, mean dose 1'7± 0'6 mg. The risk of vitamin B12 deficit is multipled by 1'8 if it is a man (RR=1'4). Those three patologies have in common more tan 4 years of diagnosis and obesity. The vitamin B12 deficit and the depressive disorder mismatch in the age. Vitamin B12 is not ordered in 91'3% of the patients. Three patients defined challenge identified in consultation nursing. Conclusions: There is under diagnosis in those three associated pathologies.

• Referencias bibliográficas
  • International Diabetes Federation. Diabetes Atlas 4th edition. Accessed May 3nd [Internet], 2010 [Citado el 18 de Dic. De 2014]. Disponible...
  • Estrategia de Diabetes del Sistema Nacional de Salud. Sanidad [Internet] 2012. Ministerio de Sanidad, Servicios Sociales e Igualdad [Citado...
  • Wile D. Association of metformin, elevated homocysteine, and methymalonic acid levels and clinically worsened diabetic peripheral neuropathy....
  • De Jager J, Kooy A, Lehert P, Wulffelé MG, van del Kol KJ, Bets D et al. Long term treatment with metformin in patients with type 2 diabetes...
  • Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr. Association of biochemical B12 deficiency with metformin therapy and vitamin B12...
  • Sánchez H, Masferrer D, Lera L, Arancibia E, Ángel B, Albala C. Déficit de Vitamina B12 asociado con altas dosis de metformina en adultos...
  • De Groot-Kamphuis DM, van Dijk PR, Groenier KH, Houwe ling ST, Bilo HJG, Kleefstra N. Vitamin B12 deficiency and the lack of its consequences...
  • Ting RZ-W, Szeto CC, Chan MH-M, Ma KK, Chow KM. Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med....
  • American Diabetes Associatión. Standars of medical care in diabetes 2013. Diabetes Care. 2013; 36(1):11-66.
  • Trento M, Raballo M, Trevisan M, Sicuro J, Passera P, Cirio L, et al. A cross-sectional survey of depression, anxiety, and cognitive function...
  • Furuya M, Hayashino Y, Tsujii S, Ishii H, Fukuhara S. Comparative validity of the WHO-5 Well-Being Index and two-question instrument for screening...
  • Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;...
  • Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clake R, Ueland PM et al. Effect of oral vitamin B-12 with or without folic acid on cognitive...
  • Kibirige D, Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? Journal...
  • Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Yoing B, et all. Collaborative Care for Patients with Depression and Chronic Illnesses....
  • Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ, et all. Depression and Diabetes Treatment Nonadherence: A Meta-Analysis....
  • Yaffe K, Lindquist K. Schwartz AV, Vitartas C, Vittinghoff E, Satterfield S, et all. Advanced glycation end product level, diabetes, and accelerated...
  • Kimy H, Lee KJ. Serum homocysteine levels are correlated with behaviora and psycholosical symptoms of Alzheimer's disease. Neuropsychiatr...
  • Alzheimer'sDisease International. World Alzheimer report [Internet]. London: Alzheimer Disease International [update 2009; Citado 2015...
  • Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Alzheimer's Disease International. Global prevalence of dementia:...
  • Taguchi A. Vascular factors in diabetes and Alzheimer's disease. J Alzheimers Dis. 2009; 16(4):859-64.
  • Wang E, Guo X, Shen X, Kream RM, Mantione KJ, Stefano GB. Vascualr dysfunction associated with type 2 diabetes and Alzheimer's disease:...
  • Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam...
  • Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA. Diabetes Mellitus and Risk of Developing Alzheimer Disease: Results From the Framingham...
  • Bruce DG, Davis WA, Casey GP, Starkstein SE, Clarnette RM, Foster JK, et al. Predictors of cognitive impairment and dementia in older people...
  • Marcuello C, Calle-Pascual AL, Fuentes M, Runkle I, Soriguer F, Goday A, et al. Evaluation of Health-Related Quality of Life according to...
  • Corriere M, Rooparinesingh N, Rastogi Kalyan R. Epidemiology of Diabetes and Diabetes Complications in the Elderly: An Emerging Public Health...
  • Mejía-Arango S, Zúñiga-Gil C. Diabetes mellitus as a risk factor for dementia in the Mexican elder population. Rev Neurol. 2011; 53(7):397-405.
  • Katon W, Lyles CR, Parker MM, Karter AJ, Huang ES, Whitmer RA. Association of depression with increased risk of dementia in patients with...
  • Biemans E, Hart HE, Rutten GE, Cuellar Renteria VG, Kooijman-Buiting AM, Beulen JW. Cobalamin status and its relation with depression, cognition...
  • Khuwaja AK, Lalani S, Dhanani R, Azam IS, Rafique G. White F. Anxiety and depression among outpatients with type 2 diabetes: A multi-centre...
  • Tovilla-Zarate C, Juárez-Rojo I, Peralta Y, Jiménez MA, Vázquez S, Bermúdez-Ocaña D, et all. Prevalence of Anxiety and Depression among Out...
  • Sullivan MD, Katon WJ, Lovato LC, Miller ME, Murray AM, Horowitz KR, et al. Association of Depression With Accelerated Cognitive Decline Among...
  • Yamazaki Y, Miwa T, Sakurai H, Hanyu H, Iwamoto T, Odawara M. Clinical backgrounds and morbidity of cognitive impairment in elderly diabetic...
  • Moore EM, Mander AG, Ames D, Kotowicz M, Carne RP, Brodaty H, et all. Increased Risk of Cognitive Impairment in Patients With Diabetes Is...
  • Lee YL, Kang HM, Kim NK, Yang JY, Noh JH, Ko KS, et all. Factors Associated for Mild Cognitive Impairment in Older Korean Adults with Type...
  • Huang CC, Chung CM, Leu HB, Lin LY, Chiu CC, Hsu CY, et all. Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based...
  • Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, et al. ADVANCE Collaborative Group Intensive blood glucose control and vascular...
  • Gerstein HC, Riddle MC, Kendall DM, Cohen RM, Goland R, Feinglos MN, et al. For the ACCORD Study Group. Glycemia treatment strategies in the...
  • Obeid R. Metformin causing vitamin B12 deficiency: a guilty verdict without sufficient evidence. Diabetes Care. 2014; 37(2):22-3.
  • Calvo JM, Ramiro JM. Vitamina b12 en pacientes diabeticos tipo 2 en tratamiento con metformina. Endocrinología y Nutrición. 2012; 59(8):487-90.