Acceso usuarios
Carolina Pino Astorga, Angel Roco Videla, David Peña Lara, Sebastián Vásquez Aliaga, Gloria Madrid Áviles, Ana María Obregón Vera, Macarena Valladares Vega
Fundamentos: El estado nutricional puede verse afectado por la conducta alimentaria y los ritmos circadianos. Estos se encuentran regulados por el gen CLOCK, cuyos alelos T del SNP rs3749474T/C y A del SNP rs4864548A/G, han sido asociados con la obesidad en adultos.
Métodos: Se evaluó a 65 sujetos usando la técnica PCR en tiempo real para determinar si era portadores del alelo T del SNP rs3749474T/C o del A del SNP rs4864548A/G. Se realizaron mediciones antropométricas, y se aplicó los cuestionarios TFEQ y el Horne-Östberg.
Resultados: De los 65 sujetos estudiados, 8 eran portadores del alelo T del SNP rs3749474T/C y 7 del A del SNP rs4864548A/G. Los portadores del alelo A presentaron mayores valores promedio de IMC (26,58), circunferencia de cintura (89,57cm) y porcentaje de grasa (31,56%) no existiendo diferencias estadísticamente significativas entre ellos. No se encontraron diferencias estadísticamente significativas en cuanto a la conducta alimentaria. El 66,67% del total de los sujetos presentó un cronotipo de tipo intermedio.
Conclusiones: Los portadores del alelo A del SNP rs4864548A/G presentarían un mayor potencial de sufrir problemas asociados a la obesidad, pero es necesario realizar estudios con poblaciones más grandes y con mejor paridad de género, que permita corroborar esta aseveración.
Background: Nutritional status may be affected by eating behavior and circadian rhythms. These are regulated by the CLOCK gene, whose T alleles of SNP rs3749474T / C and A of SNP rs4864548A / G, have been associated with obesity in adults.
Methods: 65 subjects were evaluated using the real-time PCR technique to determine whether they were carriers of the T allele of the SNP rs3749474T/C or the A of the SNP rs4864548A/G. Anthropometric measurements were made, and the TFEQ and Horne-Östberg questionnaires were applied.
Results: Of the 65 subjects studied, 8 were carriers of the T allele of the SNP rs3749474T / C and 7 of the A of the SNP rs4864548A/G. The carriers of the A allele had higher average BMI values (26.58), waist circumference (89.57cm) and fat percentage (31.56%), with no statistically significant differences between them. No statistically significant differences were found regarding eating behavior. 66.67% of the total subjects presented an intermediate type chronotype.
Conclusions: The carriers of the A allele of SNP rs4864548A/G would have a greater potential to suffer problems associated with obesity, but studies with larger populations and with better gender parity are necessary, which allows to confirm this assertion.
