Alta prevalencia de deficiencia de vitamina D en mujeres posmenopáusicas de una consulta reumatológica en Madrid: evaluación de dos pautas de prescripción de vitamina D

• Pilar Aguadoa ^[1] ; Mª Victoria Garcés ^[1] ; Mª Luisa González Casaús ^[2] ; Mª Teresa del Campo ^[1] ; Patricia Richi ^[1] ; Juan Coya ^[1] ; Antonio Torrijos ^[1] ; Juan Gijón ^[1] ; Emilio Martín Mola ^[1] ; Mª Eugenia Martínez ^[1]
  1. [1] Hospital Universitario La Paz

     Hospital Universitario La Paz

     Madrid, España

     
  2. [2] Servicio de Biopatología Clínica. Hospital Gómez Ulla. Madrid.
• Localización: Medicina clínica, ISSN 0025-7753, Vol. 114, Nº. 9, 2000, págs. 326-330
• Idioma: español
• DOI: 10.1016/S0025-7753(00)71283-8
• Títulos paralelos:
  • High prevalence of vitamin D deficiency in postmenopausal women in a outpatient rheumatological clinic from Madrid area (Spain): Evaluation of two forms of vitamin D prescription
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• Resumen

  • Background: Vitamin D deficiency has been frequently observed in the elderly population in Europe. However few information is available about the vitamin D status in postmenopausal women in the Mediterranean countries. The aim of this study was to evaluate the vitamin D status assessed by serum 25(OH)D3 (calcidiol) in postmenopausal women who attended a Rheumatology practice in Madrid area, and to evaluate calcidiol serum levels through one year after two forms of vitamin D administration.

    Patients and methods: Calcidiol serum levels were measured in 171 postmenopausal women (111 with osteoporosis and 60 without osteoporosis). 82 women with calcidiol serum levels < 10 ng/ml were distributed in two groups: Group I received 800 U/day of vitamin D3 associated with calcium (1 g/day) and group II, one dose of 80.000 U vitamin D orally as calcidiol and latter a daily dose of 800 U vitamin D3 plus 1 g calcium. Calcidiol serum levels were measured by RIA in both groups at basal condition and after three, six and twelve months under treatment.

    Results: Three cut-offs were considered: 10, 15 and 20 ng/ml of calcidiol. Percentages of postmenopausal women with vitamin D deficiency for such cut-offs were: 35.3%, 64.1% and 87.1%, respectively. After three months of treatment, women from group II showed calcidiol serum levels higher than group I. At six and twelve months calcidiol serum levels were similar in both groups.

    Conclusions: A high prevalence of vitamin D deficiency was observed in a group of postmenopausal women who attended a rheumatology practice in Madrid area. Both forms of vitamin D administration seem not sufficient to maintain the adequate calcidiol serum levels in postmenopausal deficient women. A dose of 80.000 U of calcidiol twice a year should be considered