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The study reported here was designed to investigate the relationship between depressive symptoms and occupational stress in female nurses in China during the period June–July 2008. The hypothesis tested was that social support and rational coping would mediate the effects of occupational stress on depressive symptoms. Our structural equation modeling revealed that social support and rational coping were negatively correlated with depressive symptoms. Social support and rational coping mediated the effects of occupational stress on depressive symptoms. Role overload, role insufficiency, and role boundary were predictive of depressive symptoms. These results indicated that lessening occupational stress and strengthening social support and rational coping could decrease depressive symptoms among Chinese female nurses. © 2011 Wiley Periodicals, Inc. Res Nurs Health 34:401–407, 2011
