José Luis D’Addino
Los métodos de localización preoperatoria de las paratiroides en el hiperparatiroidismo secundario son controvertidos y tienen valores de sensibilidad dispares. Con el objetivo de determinar la correlación entre ecografía preoperatoria versus centellograma sestamibi y el hallazgo intraoperatorio discutiendo su utilidad, se evaluaron 10 años de estadística. Entre 2004-2014, 100 pacientes fueron operados por hiperparatiroidismo secundario. De historias clínicas: valor de parathormona, resultados de ecografía, centellograma y anatomopatologías. Se determinó especificidad y sensibilidad para ecografía y centellograma; valores predictivos positivos y negativos correlacionándolos con el hallazgo intraoperatorio. Se utilizaron procedimientos de curvas ROC y Cálculo del área bajo la curva, además de otros valores de cribaje (índice de confianza, índice de validez y razón de verosimilitud).68% fueron mujeres; promedio etario: 52,7 años, PTH media: 1486 pg/ml. Especificidad y sensibilidad ecográfica: 94,44% y 30,14%, respectivamente, VPP de 93,62% y VPN de 33,33%. Para el centellograma, especificidad: 98,15% y sensibilidad: 25,34%, VPP de 97,37% y un VPN de 32,72%. Ecográficamente se localizaron 94 glándulas sobre 400, el centellograma 76 y la cirugía 292. Recidivas, 22%.Ecografía y centellograma permitieron ubicar preoperatoriamente paratiroides patológicas, sin embargo, el 10% de los casos no fueron evidenciadas, por lo que la experiencia del cirujano operador es fundamental para hallarlas.
Methods for preoperative localization of parathyroidin secondary hyperparathyroidism are controversial in the literature and have different and dissimilar sensitivity. With the objective to determine the correlation between preoperative ultrasound, scintigraphy MIBI and intraoperative findings in secondary hyperparathyroidism we review our 10 years statistic.Between2004-2014, 100 patients underwent parathyroidectomy due to secondary hyperparathyroidism. Data obtained from medical records included: preoperative serum parathormona, ultrasound, scintigraphy. Positive predictive value and negative predictive value were analyzed in correlation with intraoperative findings.The method of calculation of ROC curves and area under the curve and other screening values (confidence index, index of validity and likelihood ratio) were used. 68% were women; mean age was 52,7 years. Mean PTH value was 1486 pg/ml. The specificity and sensitivity of preoperative ultrasound were 94,44% and 30,14%, respectively. PPV was 93,62% and NPV was 33,33%. For scintigraphy, the sensitivity was 25,34%, specificity 98,15%, PPV was 97,37% and NPV was 32,72%. The ultrasound diagnosed 94 glands among a possibility of 400, the scintigraphy showed 76 and the surgery founded 292. Recurrence, 22%. Ultrasound and scintigraphy allow the localization of pathological parathyroid; however, in 10% of cases,glands could not be detected preoperatively, making surgeons experience fundamental in gland localization.