Resumen de Role of ApoA1 on High-Density Lipoprotein: an intervention with plant sterols in patients with hypercholesterolemia

Ismael San Mauro Martín, Luis Rodolfo Collado Yurrita, María Ángeles Cuadrado Cenzual, María José Ciudad Cabañas, Paula Mendive Dubourdieu

• Background: Numerous studies have shown an inverse association between cholesterol´s concentration associated with High-Density Lipoprotein Cholesterol (HDL-C) and cardiovascular risk. The present study intends to investigate the possible relation between Apolipoprotein A (ApoA1) and HDL-C as a new strategy to reduce cardiovascular risk.

  Aim: was determine the effect of ApoA1 in cholesterol´s metabolism through its influence on HDL-C in young adult population.

  Methods: One clinical trial, controlled, randomized, double-blind, providing a commercial milk, �Naturcol�, with sterols for 3 weeks (n = 19) and placebo (n = 16). A questionnaire Ad Hoc was designed and a complete anthropometric study was made. SPSS 21.0 was used to analyse the data.

  Results: Significant differences were observed between sterol milk and placebo in a single marker, Low-Density Lipoprotein Cholesterol (LDL-C). A linear dispersion of data between HDL-C and ApoA1 was found, both at the beginning and end of the intervention (Person Correlation = 0.846 and 0.903, respectively). High dependency measures by linear regression (R2= 0.715 and 0.816, respectively) were observed.

  Conclusion: A significant relation between HDL-C and ApoA1 was proven. Taking into account the importance that HDL-C levels seem to have on cardiovascular health, ApoA1 is presented as an important clinical marker to improve heart function as well as to reduce cardiovascular risk.