To explore what we have learned about informed advocacy from and with nurses working in rural, remote, and northern communities. Focuses on registered nurses who work in geographically isolated communities in Canada. A synthesis of the work of 2 nurse researchers drawing on critical feminist, postcolonial, and social justice theories. The following 4 types of advocacy are discussed: (1) ensuring that people's concerns are heard, (2) contextualizing practices, (3) safeguarding, and (4) addressing systemic health inequities. An informed advocacy perspective helps registered nurses make an important contribution toward improving the health of people living in rural, remote, and northern communities.