Periodontitis crónica: Una visión desde la proteómica

• Simancas Pallares, Miguel ^[1]
  1. [1] Universidad de Cartagena

     Universidad de Cartagena

     Colombia

     
• Localización: Duazary: Revista internacional de Ciencias de la Salud, ISSN-e 2389-783X, ISSN 1794-5992, Vol. 7, Nº. 1, 2010, págs. 106-116
• Idioma: español
• Enlaces
  • Texto completo (pdf)
• Resumen

  • La periodontitis resulta en un daño tisular complejo a las estructuras de soporte dentario debido al efecto dela respuesta inmune. Sin embargo, la naturaleza de los componentes de éste proceso son interés de muchosinvestigadores ya que se determinaron a través de estudios experimentales algunas moléculas de carácter proteínicoque activan y/o regulan otras sustancias ó células para el desarrollo de la lesión. El objetivo de ésta revisión deliteratura es conducir un análisis crítico de la evidencia disponible sobre las proteínas expresadas durante laperiodontitis crónica. Se identificaron las publicaciones más relevantes a través de una búsqueda en bases de datoselectrónicas como MEDLINE, EBSCO-HOST y “The Cochrane Database of Systematic Reviews”. Para ser incluídosen la revisión, los estudios debieron definir la proteína investigada, en pacientes con periodontitis crónica. De los1210 artículos obtenidos en la fase inicial de la revisión, sólo 175 estaban disponibles en texto completo y de éstossólo cumplieron los requisitos de inclusión 25 artículos, los cuales fueron confrontados, analizados y discutidosposteriormente. La evidencia disponible demuestra que las proteínas juegan un papel importante en la transducciónde señales y que utilizan diversas vías para activar compuestos químicos contribuyendo al desarrollo de lesionesperiodontales crónicas.

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