Acceso usuarios
Enrique Rodilla Sala, José Antonio Costa Muñoz, Joaquín Martín, Carmen González, José María Pascual Izuel, Josep Redón Más
Background and objectives The principal objective was to assess the prevalence of left ventricular hypertrophy (LVH) in hypertensive, never treated patients, depending on adjustment for body surface or height. Secondary objectives were to determine geometric alterations of the left ventricle and to analyze the interdependence of hypertension and obesity to induce LVH.
Patients and methods Cross-sectional study that included 750 patients (387 men) aged 47 (13, SD) years who underwent ambulatory blood pressure (ABPM) monitoring and echocardiography.
Results The prevalence of LVH was 40.4% (303 patients), adjusted for body surface area (BSA, LVHBSA), and 61.7% (463 patients), adjusted for height2.7 ( ). In a multivariate logistic analysis, systolic BP24h, gender and presence of elevated microalbuminuria were associated with both LVHBSA and . Increased waist circumference was the strongest independent predictor of , but was not associated with LVHBSA. We found a significant interaction between abdominal obesity and systolic BP24h in . Concentric remodelling seems to be the most prevalent alteration of left ventricular geometry in early stages of hypertension (37.5%).
Conclusions The impact of obesity as predictor of LVH in never treated hypertensives is present only when left ventricular mass (LVM) is indexed to height2.7. Obesity interacts with systolic BP24h in an additive but not merely synergistic manner. Systolic BP24h is the strongest determinant of LVH when indexed for BSA.
