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Background and objective To investigate the association between handedness and the side of symptom dominance in Parkinson's disease (PD).
Patients and methods One hundred and forty-six PD patients with symmetric symptoms (92 males and 54 females), aged 64.3 ± 9.1 years old, from a series of 247 PD patients were assessed for handedness and clinical features. The severity of PD was scored by unified Parkinson's disease rating scale (UPDRS) and Hoehn-Yahr staging on the �ON� state.
Results Of 134 right-handed patients (91.8%), 83 (61.7%) had an initial onset on the right side (P = 0.008), while of 12 left-handed patients (8.2%), 9 (75.0%) had an initial onset on the left side (P = 0.013). Out of right-handed patients, 103 (76.9%) had the right-side dominance of PD symptoms (P < 0.001). Among the left-handed subjects, 7 patients (58.3%) had left-sided and 5 patients (41.7%) had right-sided symptom dominance (P = 0.564). In general, dominant side of symptoms was in accordance with handedness (P = 0.008). In right-handed patients, rest tremor was the most common initial symptom (P < 0.001), while rest tremor and rigidity-bradykinesia were initial symptoms in left-handed patients (P = 0.366).
Conclusions PD symptoms emerge more often on the dominant hand-side, and the dominant side of symptoms is in accordance with handedness.
