Dermatitis atópica y trastornos del espectro autista: una mirada a su asociación y mecanismos compartidos

• Eine Yesid Benavides Tulcán ^[1] ; Sara Cano Bará ^[2] ; Edgar Andrés Lozano Ponce ^[2]
  1. [1] Universidad del Valle, Departamento de Medicina Interna, Cali, Colombia. Hospital Universitario del Valle, Cali, Colombia.
  2. [2] Universidad del Valle, Departamento de Medicina Interna, Cali, Colombia. Hospital Universitario del Valle, Cali, Colombia CLIPSO-Clínica Integral de Enfermedades Inmunomediadas de la Piel, Cali, Colombia.
• Localización: Piel: Formación continua en dermatología, ISSN 0213-9251, Vol. 41, Nº. 3 (Marzo), 2026, págs. 224-227
• Idioma: español
• DOI: 10.1016/j.piel.2025.07.018
• Títulos paralelos:
  • Atopic dermatitis and autism spectrum disorders: A look at their association and shared mechanisms
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• Resumen
  • español

    La dermatitis atópica y los trastornos del espectro autista son condiciones con un aumento de la prevalencia en las últimas décadas. Este artículo explora su asociación. La evidencia sugiere que ambas entidades comparten mecanismos fisiopatológicos, genéticos e inmunológicos, como la activación de mastocitos, citoquinas proinflamatorias (IL-6, TNF-α), deficiencia de vitamina D y genes como MIF, BDNF, SHANK3, GATA-3 y ADRB2. Además, la disfunción inmunológica y la autoinmunidad podrían contribuir a su coocurrencia. Se propone un abordaje holístico, multidisciplinar y precoz, dada la carga emocional y funcional compartida. El reconocimiento clínico de esta asociación podría mejorar el diagnóstico temprano y el manejo integral de ambos trastornos.

  • English

    Atopic dermatitis and autism spectrum disorders are conditions whose prevalence has increased in recent decades. This article explores their association. Evidence suggests that both entities share pathophysiological, genetic, and immunological mechanisms, such as mast cell activation, proinflammatory cytokines (IL-6, TNF-α), vitamin D deficiency, and genes such as MIF, BDNF, SHANK3, GATA-3, and ADRB2. Additionally, immune dysfunction and autoimmunity may contribute to their co-occurrence. A holistic, multidisciplinary, and early approach is proposed, given the shared emotional and functional burden. Clinical recognition of this association could improve early diagnosis and the comprehensive management of both disorders.

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