Comparative Study of Techniques for Restoring Function in Thrombotically Occluded Peripherally Inserted Central Catheters: An In Vitro Model Study

• Li, Feng-Xian ^[1] ; Su, Peng ^[1] ; Yue-Bing ^[1] ; Huan-Huan ^[1]
  1. [1] Department of Oncology, Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing, People’s Republic of China
• Localización: Journal of infusion nursing: the official publication of the Infusion Nurses Society, ISSN 1533-1458, ISSN-e 1539-0667, Vol. 49, Nº. 2, 2026, págs. 117-126
• Idioma: inglés
• DOI: 10.1097/NAN.0000000000000630
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  • Permissions Global Voices Comparative Study of Techniques for Restoring Function in Thrombotically Occluded Peripherally Inserted Central Catheters: An In Vitro Model Study Li, Feng-Xian BM; Su, Peng PhD; Li, Yue-Bing BM; Li, He-Wen BM; Gao, Huan-Huan BM Author Information Journal of Infusion Nursing 49(2):p 117-126, March/April 2026. | DOI: 10.1097/NAN.0000000000000630 Open Abstract Plain Language Summary Objective:

    To compare the efficacy, safety, and operational efficiency of the intermittent negative-pressure guidewire technique and the stay-locking technique in restoring the function of thrombotically occluded peripherally inserted central catheters (PICCs).

    Methods:

    An in vitro thrombotically occluded PICC model was created using 110 catheters, with successful occlusion established in 90. The experimental group comprised 43 models treated with the intermittent negative-pressure guidewire technique, while the control group included 45 models treated using the stay-locking technique. Relevant procedural data were collected and analyzed statistically.

    Results:

    The success rate was significantly higher in the experimental group (62.79%) compared with the control group (4.44%, P < .0001). There was no significant difference in the incidence of thrombus overflow at the catheter tip between groups (P = .704); however, the length of thrombus overflow was significantly greater in the control group (P = .001). Additionally, successful interventions were associated with significantly shorter operation times and significantly higher-pressure recovery rates (P < .0001 for both comparisons).

    Conclusion:

    In an in vitro model of thrombotically occluded PICCs, the intermittent negative-pressure guidewire technique demonstrated superior efficacy, including shorter operation time and higher success rates, compared with the stay-locking technique. The marked increase in the pressure recovery rate in successful cases indicates the technique’s effectiveness in restoring catheter function.