Analysis of TyG index and TG/HDL ratio with hyperuricemia in patients with H-type hypertension

• Ziqiang Luo ^[1] ; Jie Yang ^[1] ; Changyi Wang ^[1] ; Chaoying Luo ^[1] ; Hongen Chen ^[1] ; Chunfang Lv ^[1] ; Linzhen Qin ^[1] ; Lanlan Wu ^[1] ; Mei Luo ^[1] ; Zhigang Huang ^[2] ; Tao Zhang ^[1]
  1. [1] 1 Shenzhen Nanshan Center for Chronic Disease Control. Shenzhen, Guangdong. People’s Republic of China
  2. [2] r for Chronic Disease Control. Shenzhen, Guangdong. People’s Republic of China.
• Localización: Nutrición hospitalaria: Órgano oficial de la Sociedad Española de Nutrición Clínica y Metabolismo (SENPE), ISSN-e 1699-5198, ISSN 0212-1611, Vol. 43, Nº. 1, 2026, págs. 72-80
• Idioma: inglés
• DOI: 10.20960/nh.05630
• Títulos paralelos:
  • Análisis del índice TyG y la relación TG/HDL en pacientes con hiperuricemia e hipertensión de tipo H
• Texto completo no disponible (Saber más ...)
• Resumen
  • español

    Introducción: la coexistencia de hiperuricemia e hipertensión representa un importante problema de salud pública, lo que subraya la necesidad de identificar marcadores predictivos efectivos.

    Objetivos: este estudio tuvo como objetivo evaluar la correlación entre la hiperuricemia y dos índices metabólicos (el índice TyG y la relación TG/HDL) en pacientes con hipertensión de tipo H, con un análisis específico por géneros.

    Material y métodos: se seleccionó una cohorte de 7051 pacientes de un programa de cribado de riesgo de ictus en el distrito de Nanshan entre 2017-2018 y 2021-2023. Se emplearon modelos de regresión logística y splines cúbicos restringidos para evaluar el riesgo y las relaciones dosis-respuesta.

    Resultados: los cuartiles más altos de ambos índices se asociaron con un mayor riesgo de hiperuricemia, con un poder predictivo más fuerte en mujeres. Se observó una relación dosis-respuesta no lineal y lineal entre el índice TyG y la hiperuricemia en hombres y mujeres, respectivamente, mientras que la relación TG/HDL mostró una asociación no lineal en ambos géneros. No se encontró asociación entre estos índices y los niveles de homocisteína.

    Conclusiones: estos resultados sugieren que el ín

  • English

    Background: the concurrent occurrence of hyperuricemia and hypertension is a significant public health issue, highlighting the need for effective predictive markers.

    Objective: this study aimed to assess the correlation between hyperuricemia and two metabolic indices, the TyG index and the TG/HDL ratio, in H-type hypertension patients, with gender-specific analysis.

    Material and methods: a cohort of 7,051 patients was selected from a stroke risk screening program in Nanshan District between 2017- 2018 and 2021-2023. Logistic regression and restricted cubic spline modeling were used to evaluate the risk and dose-response relationships.

    Results: the highest quartiles of both indices were associated with an increased risk of hyperuricemia, with stronger predictive power in females.

    Nonlinear and linear dose-response relationships were observed between the TyG index and hyperuricemia in males and females, respectively, while the TG/HDL ratio showed a nonlinear association with hyperuricemia in both genders. No association was found between these indices and homocysteine levels.

    Conclusion: these results suggest

• Referencias bibliográficas
  • 1. Li Y, Shen Z, Zhu B, Zhang H, Zhang X, Ding X. Demographic, regional and temporal trends of hyperuricemia epidemics in mainland China from 2000...
  • 2. Fang N, Lv L, Lv X, Xiang Y, Li B, Li C, et al. China multi-disciplinary expert consensus on diagnosis and treatment of hyperuricemia and...
  • 3. Wang H, Zhang J, Pu Y, Qin S, Liu H, Tian Y, et al. Comparison of different insulin resistance surrogates to predict hyperuricemia among...
  • 4. Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol 2020;16(7):380-90....
  • 5. Zhu LJ, Shi JM, Wang T, Yu C, Zhou W, Bao HH, et al. Association Between Plasma Homocysteine Level and Hyperuricemia in Elderly Patients...
  • 6. Gois PHF, Souza ER de M. Pharmacotherapy for hyperuricemia in hypertensive patients. Cochrane Database Syst Rev 2017;4(4):CD008652. DOI: 10.1002/14651858.CD008652.pub3
  • 7. Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, et al. Asymptomatic Hyperuricemia Without Comorbidities...
  • 8. Wang B, Yang Y, Li X. Interaction of Hypertension and Insulin Resistance Exacerbates the Occurrence of Diabetes Mellitus in Healthy Individuals....
  • 9. Gastaldelli A. Measuring and estimating insulin resistance in clinical and research settings. Obesity (Silver Spring) 2022;30(8):1549-63....
  • ANALYSIS OF TyG INDEX AND TG/HDL RATIO WITH HYPERURICEMIA IN PATIENTS WITH H-TYPE HYPERTENSION 80 Z.   Luo et al. [Nutr Hosp 2026;43(1):72-80]
  • 10. Li X, Huang B, Liu Y, Wang M, Wang YX, Feng KL, et al. Association Between Different Metabolic Markers and Metabolic Syndrome in an Outpatient...
  • 11. Ding Z, Du S, Yang Y, Yu T, Hong X. Association between triglyceride glucose index and H-type hypertension in postmenopausal women. Front...
  • 12. Qian XL, Cao H, Zhang J, Gu ZH, Tang WQ, Shen L, et al. The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension...
  • 13. Tu W, Yan F, Chao B, Ji X, Wang L. Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening...
  • 14. Zhang T, Lv C, Liu K. Analysis of the Correlations of Age, Gender, Blood Uric Acid (UA) and Lipids with Plasma Homocysteine in Hypertensive...
  • 15. Wang J, Zhou J, Shao Z, Chen X, Yu Z, Zhao W. Association between serum uric acid and homocysteine levels among adults in the United States: a...
  • 16. Shi W, Xing L, Jing L, Tian Y, Liu S. Usefulness of Triglyceride-glucose Index for estimating Hyperuricemia risk: Insights from a general...
  • 17. Bao F, Cui M, Shi X, Ju S, Cong H. Distribution characteristics and influencing factors of homocyteine in an apparently healthy examined...
  • 18. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic...
  • 19. Chinese Society of Endocrinology, Chinese Medical Association. Guideline for the diagnosis and management of hyperuricemia and gout in China...
  • 20. Che B, Zhong C, Zhang R, Pu L, Zhao T, Zhang Y, et al. Triglyceride-glucose index and triglyceride to high-density lipoprotein cholesterol...
  • 21. Mohd Nor NS, Lee S, Bacha F, Tfayli H, Arslanian S. Triglyceride glucose index as a surrogate measure of insulin sensitivity in obese...
  • 22. Oliveri A, Rebernick RJ, Kuppa A, Pant A, Chen Y, Du X, et al. Comprehensive genetic study of the insulin resistance marker TG:HDL-C in...
  • 23. Liu S, Zhou Z, Wu M, Zhang H, Xiao Y. Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension:...
  • 24. Niu X, Ge X, Miao X, Bai Y, Wang Q, Tang G, et al. The relationship between new surrogate markers of insulin resistanceand the incidence...
  • 25. Cui N, Cui J, Sun J, Xu X, Aslam B, Bai L, et al. Triglycerides and Total Cholesterol Concentrations in Association with Hyperuricemia...
  • 26. Peng TC, Wang CC, Kao TW, Chan JYH, Yang YH, Chang YW, et al. Relationship between hyperuricemia and lipid profiles in US adults. Biomed...
  • 27. Qi J, Ren X, Hou Y, Zhang Y, Zhang Y, Tan E, et al. Triglyceride-Glucose Index is Significantly Associated with the Risk of Hyperuricemia...
  • 28. Yu Y, Wang J, Ding L, Huang H, Cheng S, Deng Y, et al. Sex differences in the nonlinear association of triglyceride glucose index with...
  • 29. Liu XY, Wu QY, Chen ZH, Yan GY, Lu Y, Dai HJ, et al. Elevated triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio increased...
  • 30. de Oliveira EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr 2012;4:12. DOI: 10.1186/1758-5996-4-12...
  • 31. Tack CJJ, Smits P, Willemsen JJ, Lenders JWM, Thien T, Lutterman JA. Effects of Insulin on Vascular Tone and Sympathetic Nervous System...
  • 32. Simental-Mendía LE, Simental-Mendía E, Rodríguez-Morán M, Guerrero-Romero F. Hyperuricemia is associated with the increase of insulin release...
  • 33. Kimura Y, Tsukui D, Kono H. Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. International Journal of Molecular Sciences 2021;22(22):12394....
  • 34. Xu W, Liu H, Yuan L. High uric acid induced resistance in 3T3-L1 adipocyte and its mechanism. Chinese Journal of Diabetes 2017;25(7):644-8.
  • 35. Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, uric acid, and the etiology of diabetes and obesity....
  • 36. Wan X, Xu C, Lin Y, Lu C, Li D, Sang J, et al. Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent...
  • 37. Waring WS, Webb DJ, Maxwell SR. Uric acid as a risk factor for cardiovascular disease. QJM 2000;93(11):707-13. DOI: 10.1093/qjmed/93.11.707
  • 38. Zhang X, Qu YY, Liu L, Qiao YN, Geng HR, Lin Y, et al. Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance...
  • 39. McMullan CJ, Borgi L, Fisher N, Curhan G, Forman J. Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory...