Acceso usuarios
Walter Sepúlveda Loyola, Yshoner Antonio Silva Díaz, Cintya Elisabeth Odar Rojas, Ruth Clarivel Vega Rojas, Andressa Keiko Matsumoto, Denilson Teixeira, Vanessa Suziane Probst
Introduction: The association among important blood biomarkers with Phase angle (PhA) has not yet been specifically explored.
Objective: To analyze the association between PhA and blood biomarkers, including BDNF, oxidative stress, metabolism, and vitamins, in community-dwelling older adults.
Methods: A cross-sectional study with 169 older adults from Londrina, Brazil. PhA was measured using bioimpedance. Blood biomarkers from peripheral blood test were analyzed in all individuals after 10 hours of overnight fasting. Brain-derived neurotrophic factor (BDNF), Nitric Oxide (NO); Advanced Oxidation Protein Products (AOPP), Ferrous Oxidation in Xylenol orange (FOX); Glutathione Transferase (GSH); Total Plasma Antioxidant Potential (TRAP); Total Plasma Sulfhydryl (SH); Catalase (CAT); Superoxide Dismutase (SOD), Vitamin D and Vitamin B12 were analyzed. A linear regression model was performed to analyze the association between Blood biomarkers and PhA, considering Model 1 (unadjusted analysis) and Model 2 (adjusted for age and sex). Statistical significance was considered as p < 0.05 Results: The mean age of the participants was 70.17 ± 7.14 years, with 81.07% women. Significant associations were observed between PhA and BDNF (β = 3.43x10⁻⁴, p = 0.04) and FOX (β = -8.01x10⁻¹, p = 0.03) in unadjusted analyses. After adjusting for age and sex, the associations remained significant for BDNF (β = 3.51x10⁻⁴, p = 0.04) and FOX (β = -7.60x10⁻¹, p = 0.04).
Conclusions: BDNF and FOX are the main blood biomarkers related with PhA in community-dwelling older adults.
