Specifi c dietary micronutrients are causally associated with arthritis subtypes: Results from the nhanes 2015-2018 and mendelian randomization study

• Feng Cheng ^[1] ; Yingjia Zhu ^[2] ; Xiaojing Zhang ^[1] ; Fei Xia ^[1]
  1. [1] Zhejiang Chinese Medical University

     Zhejiang Chinese Medical University

     China

     
  2. [2] Department of Gynecology. Hangzhou Women’s Hospital;
• Localización: Nutrición hospitalaria: Órgano oficial de la Sociedad Española de Nutrición Clínica y Metabolismo (SENPE), ISSN-e 1699-5198, ISSN 0212-1611, Vol. 42, Nº. 5, 2025, págs. 984-994
• Idioma: inglés
• DOI: 10.20960/nh.05795
• Títulos paralelos:
  • Micronutrientes dietéticos específi cos se asocian causalmente con los subtipos de artritis: Resultados basados en el estudio nhanes 2015-2018 y el estudio de aleatorización mendeliana
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• Resumen
  • español

    Introducción: los micronutrientes (MN) de la dieta están relacionados con la artritis, pero las relaciones causales y los efectos dependientes de la dosis siguen sin aclararse.

    Métodos: utilizando la Encuesta Nacional de Examen de Salud y Nutrición (NHANES) y bases de datos de estudios de asociación del genoma completo (GWAS), se aplicaron la regresión logística multivariante, splines cúbicos restringidos (RCS) y la aleatorización mendeliana (MR) para analizar el impacto de los MN en la artritis.

    Resultados: la regresión logística multivariada identificó seis MN significativamente asociados con la artritis: calcio (OR = 0,74 [IC 95 %, 0,60, 0,92] p = 0,013), magnesio (OR = 0,74 [IC 95 %, 0,62, 0,89] p = 0,003), selenio (OR = 0,62 [IC 95 %, 0,50, 0,76] p = 0,0001), ácido fólico (OR = 0,76 [IC 95 %, 0,61, 0,94] p = 0,018), vitamina E (OR = 0,77 [IC 95 %, 0,64, 0,92] p = 0,01), vitamina B6 (OR = 0,64 [IC 95 %, 0,53, 0,78] p = 0,0001). El análisis RCS reveló relaciones no lineales significativas para la vitamina B6 , la vitamina E, el ácido fólico y el selenio (p < 0,05).

    El análisis de MR solo confirmó asociaciones causales entre MN específicos y subtipos de artritis: calcio y artritis reumatoide (OR = 0,648 [IC 95 %, 0,436, 0,962] p = 0,031), vitamina B12 y monoartritis (OR = 2,876 [IC 95 %, 1,240, 6,667] p = 0,014), potasio y artritis piógena (OR = 2,124 [IC 95 %, 1,003, 4,497] p = 0,049), vitamina B6 y artritis piógena (OR = 1,744 [IC 95 %, 1,034, 2,940] p = 0,037), vitamina B12 y otras artritis (OR = 1,414 [IC 95 %, 1,035, 1,932] p = 0,03), Conclusiones: este estudio revela asociaciones causales entre MN específicos y subtipos específicos de artritis, al mismo tiempo que observa relaciones dosis-dependientes entre otros MN y la artritis. Estos hallazgos aportan valiosas perspectivas para las intervenciones dietéticas y estrategias preventivas dirigidas específicamente a la artritis

  • English

    Background: micronutrients (MNs) in the diet are linked to arthritis, but the causal relationships and dose-dependent effects remain unclear.

    Methods: using the National Health and Nutrition Examination Survey (NHANES) and genome-wide association studies (GWAS) databases, multivariate logistic regression, restricted cubic splines (RCS), and Mendelian randomization (MR) were applied to analyze MNs’ impact on arthritis.

    Results: multivariate logistic regression identifi ed six MNs signifi cantly associated with arthritis: calcium (OR = 0.74 [95 % CI, 0.60, 0.92] p = 0.013), magnesium (OR = 0.74 [95 % CI, 0.62, 0.89] p = 0.003), selenium (OR = 0.62 [95 % CI, 0.50, 0.76] p = 0.0001), folic acid (OR = 0.76 [95 % CI, 0.61, 0.94] p = 0.018), vitamin E (OR = 0.77 [95 % CI, 0.64, 0.92] p = 0.01), vitamin B6 (OR = 0.64 [95 % CI, 0.53, 0.78] p = 0.0001). RCS analysis revealed signifi cant non-linear relationships for vitamin B6 , vitamin E, folic acid, and selenium (p < 0.05). MR analysis only confi rmed causal associations in specifi c MNs and subtypes of arthritis: calcium and rheumatoid arthritis (OR = 0.648 [95 % CI, 0.436, 0.962] p = 0.031), vitamin B12 and monoarthritis (OR = 2.876 [95 % CI, 1.240, 6.667] p = 0.014), potassium and pyogenic arthritis (OR = 2.124 [95 % CI, 1.003, 4.497] p = 0.049), vitamin B6 and pyogenic arthritis (OR = 1.744 [95 % CI, 1.034, 2.940] p = 0.037), vitamin B12 and other arthritis (OR = 1.414 [95 % CI, 1.035, 1.932] p = 0.03).

    Conclusions: this study reveals the causal relationship between specifi c MNs and certain arthritis subtypes, while also observing dose-dependent associations between other MNs and arthritis. These fi ndings provide valuable insights for dietary interventions and preventive strategies targeting arthritis

• Referencias bibliográficas
  • 1. Song P, Cui Z, Hu L. Applications and prospects of intra-articular drug delivery system in arthritis therapeutics. J Control Release 2022;352:946-60....
  • 2. Duca LM, Helmick CG, Barbour KE, Guglielmo D, Murphy LB, Boring MA, et al. Self-Management Education Class Attendance and Health Care Provider Counseling...
  • 3. Berger MM, Shenkin A, Schweinlin A, Amrein K, Augsburger M, Biesalski H-K, et al. ESPEN micronutrient guideline. Clin Nutr 2022;41:1357-424....
  • 4. Bañuls-Mirete M, Ogdie A, Guma M. Micronutrients: Essential Treatment for Inflammatory Arthritis? Curr Rheumatol Rep 2020;22:87. DOI: 10.1007/ s11926-020-00962-z
  • 5. Farsijani S, Mao Z, Cauley JA, Newman AB. Comprehensive assessment of chrononutrition behaviors among nationally representative adults:...
  • 6. Wessels I, Rink L. Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D. J Nutr Biochem 2020;77:108240....
  • 7. Yin Y, Dong Y, Cao Y, Dong G. Association of Vitamin E Intake with AllCause Mortality Among Individuals with Rheumatoid Arthritis: A Cohort Study...
  • 8. Lin Z, Pan W. A robust cis-Mendelian randomization method with application to drug target discovery. Nat Commun 2024;15:6072. DOI: 10.1038/ s41467-024-50385-y
  • 9. Hu X, Cai M, Xiao J, Wan X, Wang Z, Zhao H, et al. Benchmarking Mendelian randomization methods for causal inference using genome-wide...
  • 10. Kim JY, Song M, Kim MS, Natarajan P, Do R, Myung W, et al. An atlas of associations between 14 micronutrients and 22 cancer outcomes:...
  • 11. Qiu Y, Li C, Huang Y, Wu C, Li F, Zhang X, et al. Exploring the causal associations of micronutrients on urate levels and the risk of...
  • 12. Rizzoli R, Biver E, Brennan-Speranza TC. Nutritional intake and bone health. Lancet Diabetes Endocrinol 2021;9:606-21. DOI: 10.1016/S2213- 8587(21)00119-4
  • 13. Warensjö Lemming E, Byberg L, Höijer J, Larsson SC, Wolk A, Michaëlsson K. Combinations of dietary calcium intake and mediterranean-style...
  • 14. Yu Z, Li Y, Ba DM, Veldheer SJ, Sun L, Geng T, et al. Trends in Calcium Intake among the US Population: Results from the NHANES (1999–2018)....
  • 15. Cracknell RO, Tavassoli T, Field DT. High-dose Vitamin-B6 reduces sensory over-responsivity. J Psychopharmacol 2024;38(12):1147-56. DOI: 10.1177/02698811241271972
  • 16. Wolffenbuttel BH, Owen PJ, Ward M, Green R. Vitamin B12. BMJ 2023;383:e071725. DOI: 10.1136/bmj-2022-071725
  • 17. Offringa AK, Bourgonje AR, Schrier MS, Deth RC, van Goor H. Clinical implications of vitamin B12 as redox-active cofactor. Trends Mol...
  • 18. Simonenko SY, Bogdanova DA, Kuldyushev NA. Emerging Roles of Vitamin B12 in Aging and Inflammation. Int J Mol Sci 2024;25:5044. DOI: 10.3390/ ijms25095044
  • 19. Sobczyńska-Malefora A, Delvin E, McCaddon A, Ahmadi KR, Harrington DJ. Vitamin B12 status in health and disease: a critical review. Diagnosis...
  • 20. Silverstein WK, Cheung MC, Lin Y. Vitamin B12 deficiency. CMAJ 2022;194:E843. DOI: 10.1503/cmaj.220306
  • 21. Elizabeth KE. Folate: Its Biological Interactions and Strategies to Achieve Sufficiency Without Causing Excess. Am J Public Health 2021;111:347-9....
  • 22. Asbaghi O, Ashtary-Larky D, Bagheri R, Nazarian B, Pourmirzaei Olyaei H, Rezaei Kelishadi M, et al. Beneficial effects of folic acid supplementation...
  • 23. Lu YJ, Wheeler LW, Chu H, Kleindl PJ, Pugh M, You F, et al. Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation...
  • 24. Zaaboul F, Liu Y. Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects. Compr Rev Food Sci Food Saf 2022;21:964-98....
  • 25. Asbaghi O, Sadeghian M, Nazarian B, Sarreshtedari M, Mozaffari-Khosravi H, Maleki V, et al. The effect of vitamin E supplementation on...
  • 26. Kang D, Lee J, Wu C, Guo X, Lee BJ, Chun J-S, et al. The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies. Exp...
  • 27. Zheng C, Wu A, Zhai X, Ji H, Chen Z, Chen X, et al. The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles...
  • 28. Michos ED, Cainzos-Achirica M, Heravi AS, Appel LJ. Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus...
  • 29. Panda SK, Peng V, Sudan R, Ulezko Antonova A, Di Luccia B, Ohara TE, et al. Repression of the aryl-hydrocarbon receptor prevents oxidative...