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Background: The FTO gene has been widely studied, and numerous research findings have demonstrated that variants like rs9939609 are strongly related to increased body mass index (BMI), adiposity, and a heightened obesity risk. However, no study was conducted on the FTO rs9939609 gene variant among Sundanese obese young women. This study to identify the prevalence and distribution of the Fat Mass and Obesity-Related (FTO) rs9939609 polymorphism among Sundanese obese young women.
Methods: In this cross-sectional study, 38 Sundanese women aged between 18 and 25 y.o. were included. These women had been classified as obese, with a total body fat higher than 35%. FTO rs9939609 genotyping was performed using PCR and sequencing method.
Results: Our findings revealed that 50% of the subjects had the heterozygous variant TA, 42.1% had the homozygous variant TT, and only 7.9% had the variant AA homozygote. Chi-square test showed that the FTO rs9939609 variant among subjects was in Hardy-Weinberg equilibrium (p > 0.05), and the minor allele frequency was 0.329. These results provide the first insights into the prevalence of FTO rs9939609 variation among Sundanese obese women, making a contribution to obesity research and clinical practice.
Conclusions: The minor allele frequency obtained aligns with global patterns of FTO variants, suggesting a genetic predisposition to obesity. The results of this study can be a basis for further research such as obesity interventions among Sundanese obese women.
