Asociación de HSP60 de Chlamydia trachomatis y desarrollo de cáncer de ovario

• Jutinico Shubach, Adriana Paola ^[1] ; González Devia, Johanna Lizeth ^[1] ; Sánchez Mora, Ruth Mélida ^[1]
  1. [1] Universidad Colegio Mayor de Cundinamarca

     Universidad Colegio Mayor de Cundinamarca

     Colombia

     
• Localización: NOVA, ISSN-e 2462-9448, ISSN 1794-2470, Vol. 15, Nº. 28, 2017, págs. 57-68
• Idioma: español
• DOI: 10.22490/24629448.2079
• Enlaces
  • Texto completo
• Dialnet Métricas: 1 Cita
• Resumen

  • Las proteínas de choque térmico (HSP) son una familia de proteínas altamente conservadas cuya expresión se regula por la exposición a condiciones de estrés. Chlamydia trachomatis (CT) es una bacteria intracelular obligada de transmisión sexual causante de infección crónica y persistente que posibilita la expresión de proteínas tipo HSP, una de estas proteínas es la HSP60 Clamidial (cHSP60) que posee una homología del 50% con respecto a la proteína HSP60 humana. Estarevisión presenta estudios immunoepidemiológicos que han demostrado una asociación entre la respuesta inmune a cHSP60 y secuelas de la infección por CT generadas por la inflamación crónica, una de estas secuelas probablemente es el desarrollo de cáncer de ovario, patología que según la OMS es uno de los cánceres ginecológicos más letales y ocupa el quinto lugar en muertes por cáncer entre las mujeres. En esta revisión se discute como la presencia de la cHSP60 ocasiona una respuesta de anticuerpos prolongada como una fuente de estimulación antigénica e inflamación crónica, ocasionando reactividad cruzada que se asocia al desarrollo de cáncer de ovario.

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